摘要
以4-氟苯基硫脲和乙氧基甲叉基丙二酸二乙酯(DEMM)为起始原料,通过环合、烷基化、氧化、水解、加成、威廉姆逊醚合成等一系列反应,合成了7个2-位具有不同取代基团的标题化合物。其结构经1HNMR、13CNMR和ESI-MS表征。
A series of seven ethyl-3-（ 4-fluorophenyl）-4（ 3H）-pyrimidinone-5-carboxylates with varying substituents at the 2-position was synthesized from（ 4-fluorophenyl） thiourea and diethyl ethoxymethylene malonate via a sequence of reactions including cyclization,alkylation,oxidation,hydrolysis,addition and Williamson ether synthesis. The structures were confirmed by1 HNMR,13CNMR and ESI-MS.
出处
《化学试剂》
CAS
北大核心
2016年第11期1125-1128,共4页
Chemical Reagents
关键词
嘧啶酮衍生物
合成
医药中间体
pyrimidinone derivatives
synthesis
pharmaceutical intermediates
