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早期乳腺癌保乳术后单导管球囊近距离加速部分乳腺放疗单组率的Meta分析 被引量:4

Mammo Site Balloon Brachytherapy for Accelerated Partial Breast Irradiation Following Breast-conserving Surgery for Patients with Early Stage Breast Cancer:A Single Arm Meta-analysis
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摘要 目的系统评价早期乳腺癌保乳术后单导管球囊近距离加速部分乳腺放疗的美容效果及不良反应。方法计算机检索EMbase、MEDLINE、CNKI、CBM和Wan Fang Data,收集所有球囊治疗早期乳腺癌的临床研究,检索时间从建库截至2016年3月。采用AHRQ量表评价纳入横断面研究的偏倚风险,采用Open Meta、Stata软件进行Meta分析。结果共纳入20个病例系列研究,共3 796例患者。单组率的Meta分析结果显示:美容效果良好率为93%[95%CI(0.91,0.96)],5年同侧乳房内复发率为3%[95%CI(0.020,0.040)]。结论早期乳腺癌保乳术后单导管球囊近距离加速部分乳腺放疗的美容效果较好,局部复发率更低。受纳入研究数量和质量所限,上述结论可能存在偏倚,需开展前瞻性随机对照试验予以验证。 Objective To assess the cosmetic outcomes and adverse events of MammoSite balloon brachytherapy for Accelerated Partial Breast Irradiation following breast-conserving surgery for patients with early stage breast cancer. Methods We searched PubMed, EMbase, Chinese Biomedical Database, Chinese Studies Online, China Journal Fulltext Database up to March 2016, to collect clinical trials about MammoSite balloon brachytherapy following breastconserving surgery for early stage breast cancer. And meta-analyses were performed by OpenMeta and Stata softwares.Results Twenty trials involving 3 796 patients were enrolled. The single arm meta-analysis results showed that: the cosmetic results were rated as excellent to good in 93% (95%CI 0.91 to 0.96), and the 5-year incidence of ipsilateral breast tumor recurrence (IBTR) was 3% (95%CI 0.020 to 0.040). Conclusion To carry out the conclusion above, we still need controlled trials, especially randomized controlled trials (RCTs) to prompt further verification.
出处 《中国循证医学杂志》 CSCD 2016年第11期1298-1305,共8页 Chinese Journal of Evidence-based Medicine
基金 甘肃省技术研究与开发专项计划(编号:1004TCYA006) 西部放射治疗协会项目(编号:CSWOG-RTOG 2011/2)
关键词 乳腺癌 保乳术 球囊 近距离加速放疗 单组率 病例系列 系统评价 Breast carcinoma Breast-conserving therapy MammoSite Accelerated partial breast irradiation (APBI) Single arm Case series Systematic review
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