足细胞相关分子在临床诊治实践中的意义与思考

Significance of podocyte-related molecules in clinical practice of diagnosis and treatment and some thoughts about it

蛋白尿是儿童肾脏疾病最为常见的临床症状,在其发生和进展的分子机制中,足细胞起到非常重要的作用,越来越多的足细胞相关分子已经被证实与蛋白尿发生的分子机制相关,但是在蛋白尿的诊疗中,这些分子还没有被真正地转化为临床所用。该文以足细胞致蛋白尿发生的分子机制为切入点,探讨其在蛋白尿的监测和治疗两个方面的进展及思考。

Proteinuria is the most common manifestations of pediatric renal diseases. During the development and process of proteinuria,podocytes have played a very important role. A growing number of podocyte-related molecules have been confirmed to be associated with the molecular mechanisms of proteinuria. However,there are few studies focusing on the role of podocyte-related molecules in the diagnosis and treatment of proteinuria. Due to the lack of real transformation from bench to bed situation,the present paper will discuss the role of podocyte in the monitoring and treatment of proteinuria based on the podocytes’ role in mechanisms of proteinuria.