α-硫辛酸联合甲钴胺治疗对糖尿病神经源性膀胱患者尿流动力学及神经氧化损伤程度的影响

Effect of α-lipoic acid combined with mecobalamine therapy on urodynamics and oxidative damage of nerve in patients with diabetic neurogenic bladder

目的:分析α-硫辛酸联合甲钴胺治疗对糖尿病神经源性膀胱患者尿流动力学及神经氧化损伤程度的影响。方法:78例糖尿病神经源性膀胱患者随机分为观察组及对照组各39例,对照组接受常规治疗,观察组接受常规治疗+α-硫辛酸联合甲钴胺治疗。治疗前及治疗后1个疗程时,分别测定两组尿流动力学指标、周围神经传导潜伏时间、血清学指标。结果:治疗1个疗程后,两组RUV、Pdet、FS、T、C值以及ROS、MDA、SP、NPY、ChAT含量均显著低于治疗前,MFR值以及GSH、SOD、BDNF、CNTF含量均显著高于治疗前,正中神经、尺神经感觉传导潜伏时间以及正中神经、腓神经运动传导潜伏时间短于治疗前(P<0.05);且观察组治疗后的RUV、Pdet、FS、T、C值以及ROS、MDA、SP、NPY、ChAT含量均显著低于对照组,MFR值以及GSH、SOD、BDNF、CNTF含量显著高于对照组,正中神经、尺神经感觉传导潜伏时间以及正中神经、腓神经运动传导潜伏时间均显著短于对照组(P<0.05)。结论:α-硫辛酸联合甲钴胺治疗可优化糖尿病神经源性膀胱患者尿流动力学,同时降低神经氧化损伤,是治疗此类疾病的有效方案。

Objective： To analyze the effect of α-lipoic acid combined with mecobalamine therapy on urodynamics and oxidative damage of nerve in patients with diabetic neurogenic bladder. Methods： A total of 78 patients with diabetic neurogenic bladder were randomly divided into observation group and control group （n = 39）, control group received conventional therapy and observation group received conventional therapy ～ a-lipoic acid combined with mecobalamine therapy. Before treatment and after one course of treatment, urodynamic indexes, peripheral nerve conduction latency time and serum indexes of two groups were detected respectively. Results： After one course of treatment, RUV, Pdet, FS, T and C value as well as ROS, MDA, SP, NPY and ChAT content of both groups were significantly lower than those before treatment, MFR value as well as GSH, SOD, BDNF and CNTF content was significantly higher than those before treatment, and the sensory conduction latency time of median nerve and ulnar nerve as well as motor conduction latency time of median nerve and peroneal nerve were shorter than those before treatment （P＇（0.05） ; RUV, Pdet, FS, T and C value as well as ROS, MDA, SP, NPY and ChAT content of observation group were significantly lower than those of control group, MFR value as well as GSH, SOD, BDNF and CNTF content was significantly higher than those of control group, and the sensory conduction latency time of median nerve and ulnar nerve as well as motor conduction latency time of median nerve and peroneal nerve were significantly shorter than those of con- trol group （P〈0.05）. Gonclusion： α-lipoic acid combined with mecobalamine therapy can optimize the urodynamics in patients with diabetic neurogenic bladder and also reduce the oxidative damage of nerve, and it is an effective solution for treatment of such disease.