抗PD-1/PD-L1单抗在肿瘤免疫治疗中的应用

Application of anti-PD-1/PD-L1 antibodies in cancer immunotherapy

程序性死亡受体-1(programmed death receptor-1,PD-1)/程序性死亡配体-1(programmed death ligand-1,PD-L1)信号通路是介导肿瘤免疫逃逸的主要机制之一,PD-1/PD-L1的单克隆抗体已经在肿瘤的治疗中取得显著的效果。本文对抗PD-1/PD-L1治疗的机制、在临床中的应用及研究进展、抗PD-1/PD-L1治疗与其他治疗的联合治疗等进行综述。探讨PD-1/PD-L1抑制剂在肿瘤治疗中的应用。

The programmed cell death 1 （PD-1）/PD-1 ligand 1 （PD-L1） signaling pathway is an important pathway in inducing the immune escape of cancer. PD-1/PD-L1 antibodies have achieved significant effects in the treatment of tumors, especially solid tumors. In this article, we reviewed the mechanism, research progress, clinical application and the combination therapy of PD-1/PD-L1 inhibitors, and discussed the application of PD-1/PD-L1 inhibitors in clinic.