半夏白术天麻汤加味治疗高血压病50例

Fifty Cases of Primary Hypertension Treated with Supplemented Pinellia and Atractylodes Macrocephala and Gastrodia Decoction

目的:观察半夏白术天麻汤加味治疗高血压病的临床疗效。方法:选取本院2012年9月—2013年9月收治的高血压病患者100例,辨证分型为痰湿壅盛型。按照随机数字表法将患者分为观察组和对照组,每组50例。对照组给予口服缬沙坦治疗,观察组给予半夏白术天麻汤加味治疗。观察两组患者中医证候积分、临床疗效、收缩压和舒张压变化、血脂变化以及不良反应。结果:治疗后,两组患者中医证候评分均较治疗前有明显改善,差异均具有统计学意义(P<0.05或P<0.01),且观察组在改善头晕头痛、胃脘痞闷等积分上明显优于对照组,差异具有统计学意义(P<0.05或P<0.01);两组收缩压、舒张压均较治疗前有明显下降,差异具有统计学意义(P<0.01),两组收缩压和舒张压改善程度相当,差异无统计学意义(P>0.05);观察组三酰甘油水平改善程度、低密度脂蛋白改善程度明显优于对照组,差异具有统计学意义(P<0.05);观察组有效率为86%,对照组有效率为82%,两组比较差异无统计学意义(P>0.05);两组治疗期间未出现明显不良反应。结论:半夏白术天麻汤加味治疗高血压病疗效显著,可有效改善患者临床症状和体征,具有明显的调脂作用。

Objective： To observe the clinical curative effect of Supplemented Pinellia and Atractylodes Macrocephala and Gastro- dia Decoction on primary hypertension. Methods： One hundred patients with primary hypertension who were treated in our hospi- tal between Sept. of 2012 and Sept. of 2013 were diagnosed as phlegm-dampness-blockage type. They were divided into the ob- servation group and the control group according to random number table method,with 50 cases in each group. The ones in the control group were given valsartan for oral administration, while the ones in the observation group were treated with Supplemented Pinellia and Atractylodes Maerocephala and Gastrodia Decoction. Then TCM syndrome score, the clinical effect, the changes of Systolic blood pressure and diastolic blood pressure, the change of fat and the adverse reaction of the two groups were observed. Results： After the treatment, the TCM syndrome scores of the two groups were obviously improved,and all the differences between them had statistic.,d significance （P 〈0.05 or P 〈0.01 ） ;The improved scores of dizziness, headache and fullness in stomach of the observation group were obviously better than those of the control group, and ＇all the differences between them had statistical sig- nificance （P 〈0.05 or P 〈 0.01 ）. Systolic blood pressure and diastolic blood pressure of the two groups were obviously de- creased compared with before the treatment,and the differences between them had statistical significance （P 〈0.01 ）. Their im- proved degrees were nearly equal, and all the differences between them had no statistical significance （ P 〉 0.05 ）. The improved degrees of triglyceride level and low density lipoprotein level of the observation group were obviously better than those of the con- trol group,and all the differences between them had statistical significance （ P 〈 0.05 ）. The effective rate of the observation group was 86% ,while that of the control group was 82% , and the difference between them had no statistical significance （ P 〉 0.05 ）. During the treatment, there were no obvious adverse reactions in the two groups. Conclusion： Supplemented Pinellia and Atractylodes Macroeephala and Gastrodia Decoction has remarkable clinical curative effect, can greatly improve the clinical symp- toms and physical signs of patients with primary hypertension,and regulate their fat level.