和肝法治疗原发性痛经气滞血瘀证26例

Twenty-Six Cases with Primary Dysmenorrhea of Qi Stagnation and Blood Stasis Type Treated by Harmonizing the Liver

目的:观察和肝法治疗原发性痛经气滞血瘀证的临床疗效。方法:将70例就诊于江西中医药高等专科学校附属医院原发性痛经气滞血瘀证患者随机分为成药组24例、西药组20例和治疗组26例。成药组给予痛经宝颗粒,饭后温开水冲服,每次1袋,每日2次;西药组给予布洛芬缓释胶囊,每次1粒,每日2次,月经来潮后服至痛止;治疗组给予和肝止痛汤。观察3组患者的临床疗效及治疗前后痛经积分、血清前列腺素2α(Prostaglandin 2α,PGF2α)变化情况。结果:治疗后3个月3组患者痛经积分及血清PGF2α水平比较,差异无统计学意义(P>0.05);3组患者治疗后6个月痛经积分与PGF2α水平均较治疗前显著下降,且治疗组优于其他两组,差异具有统计学意义(P<0.01)。成药组有效率为68.42%,西药组有效率为38.89%,治疗组有效率为90.47%,治疗组与其他两组比较,差异具有统计学意义(P<0.05)。结论:和肝法治疗原发性痛经气滞血瘀证临床疗效显著,可显著改善患者的临床症状。

Objective： To observe the clinical curative effect of harmonizing the liver on primary dysmenorrhea of qi stagnation and blood stasis type. Methods ： Totally 70 patients primary dysmenorrhea of qi stagnation and blood stasis type treated in the Affilia- ted Hospital of Jiangxi College of Traditional Chinese Medicine were randomly divided into patent medicine group （24 cases ） , western medicine group （20 cases ） and treatment group （26 cases ）. Patent medicine group were given Tongjingbao Granules which were administered with warm boiled water after meals, 1 bag every time and twice a day ; western medicine group were giv- en Ibuprofen Sustained-Release Capsules, 1 tablet each time and twice a day until disappearance of pain during menstruation; treatment group were given Liver-Harmonizing and Pain-Relieving Decoction. The clinical effects , the changes of the dysmenor- rhea scores and serum prostaglandin 2α （PGF2a） after the treatment were observed. Restdts： After three months treatment, the difference of the dysmenorrhea score and level of serum PGF2abetween the three groups has no statistical significance （P 〉 0.05 ）. After six months of treatment, tile dysmenon＇hea score and level of serum PGF2α in three groups declined significantly, and treatment group was better than the other two groups ; the difference had statstial significance （ P 〈 0.01 ）. The effective rate was 68.42% in patent medicine group, 38.89% in western medicine group and 90.47 in treatment group ; the difference be- tween treatment group and the other two groups had statistical signitlcance （ P 〈 0.05 ）. Conclusion ： The method of harmonizing the liver has remarkable therapeutic effects on primary dysmenorrhea of qi stagnation and blood stasis type, which can significant- ly improve the clinical symptom of the patients.