丹参川芎嗪注射液对急性脑梗死老年患者血清血管细胞间黏附分子-1、细胞间黏附分子-1、内皮素-1和一氧化氮水平的影响

Effect of Danshen Chuanxiongqin injection on serum VCAM-1,ICAM-1,ET-1 and NO in elderly patients with acute cerebral infraction

目的观察丹参川芎嗪注射液对急性脑梗死老年患者血清血管细胞间黏附分子-1(VCAM-1)、细胞间黏附分子-1(ICAM-1)、内皮素-1(ET-1)和一氧化氮(NO)水平的影响。方法将168例急性脑梗死老年患者随机分为2组,对照组84例给予常规内科治疗,观察组84例在对照组治疗基础上加用丹参川芎嗪注射液治疗;比较2组临床效果以及治疗前后VCAM-1、ICAM-1、ET-1与NO水平。结果治疗2周后,观察组临床总有效率明显高于对照组(P<0.05),神经功能缺损程度评分、Barthel指数显著优于对照组(P均<0.05),血清VCAM-1、ICAM-1、ET-1、NO水平下降幅度均显著高于对照组(P均<0.05);2组均未见严重不良反应。结论丹参川芎嗪注射液治疗老年急性脑梗死的临床疗效确切,能够有效降低患者血清VCAM-1、ICAM-1、ET-1、NO水平,用药安全性高,具有较高的临床应用价值。

Objective It is to observe the effects of Danshen Chuanxiongqin injection on serum vascylar cell adhesion mol- ecule - l （ VCAM - 1 ） , intercellular adhesion molecule - 1 （ ICAM 1 ） , endothelin - 1 （ ET - 1 ） and NO in elderly patients with acute cerebral infraction. Methods 168 elderly patients with acute cerebral infraction were randomly divided into two groups ： control group （ n - 84） treated with normal medical therapy, observation group （n = 84） treated with Danshen Chua- nxiongqin injection combined with normal medical therapy. The curative effect and the changes of serum levels of VCAM - 1, ICAM - 1, ET - 1 and NO before and after treatment were observed and compared. Results After two weeks＇treatment, the to- tal effective rate in observation group was significantly higher than that in control group（ P 〈 0.05 ） , NIHSS scores, Barthel in- dex were better, the decrease of levels of serum VCAM - 1, ICAM - 1, ET - 1 and NO were more than those in control group （ P 〈 0.05 ）. No severe side effect was found in both groups. Conclusion Danshen Chuanxiongqin injection has a good clinical curative effect on elderly acute cerebral infarction, which can effectively decrease serum levels of VCAM - 1, ICAM - 1, ET - i 1 and NO with a good safety and high applicating value.