吉西他滨联合顺铂对非小细胞肺癌不同中医证型的疗效及毒副作用的观察

Efficacy and toxicity of gemcitabine combined with cisplatin in the treatment of non-small cell lung cancer with different TCM syndromes

目的:观察吉西他滨联合顺铂(GP)治疗不同中医证型中晚期非小细胞肺癌的临床症状改善情况、疗效及毒副反应。方法:观察2015年1月至2016年1月我院收治的中晚期非小细胞肺癌患者,按照中医辨证分为气虚证、阴虚证及痰湿证各20例,均给予GP方案化疗。21天为1个周期,治疗4个周期后评价疗效。结果:GP方案在改善咳嗽症状方面,气虚证、阴虚证优于痰湿证,在改善气短症状方面,痰湿证优于气虚证、阴虚证;GP方案在化疗有效率方面,痰湿证高于气虚证、阴虚证;GP方案在化疗毒副反应方面,气虚证、阴虚证较痰湿证重。结论:GP方案对中晚期NSCLC各种中医证型均有一定疗效,其中对痰湿证总体疗效更为显著,毒副反应也相对较小。

Objective: To observe the improvement of clinical symptoms, efficacy and toxicity of gemcitabine combined with cisplatin(GP) in the treatment of advanced non small cell lung cancer with different TCM syndrome types. Methods: from January 2016 to January2015 in our hospital were treated in patients with advanced non-small cell lung cancer patients, according to TCM syndrome differentiation isdivided into qi deficiency, yin deficiency and phlegm dampness syndrome accounted for 20 cases. GP regimen chemotherapy. 21 days for 1 cycles, 4 cycles after treatment evaluation of efficacy. Results: GP regimen in improving cough symptoms, syndrome of deficiency of qi and yindeficiency syndrome is better than that of phlegm dampness syndrome, in improving the symptoms of shortness of breath, phlegm dampnesssyndrome is better than that of qi deficiency, yin deficiency syndrome; GP regimen in chemotherapy efficiency and phlegm dampness syn-drome is higher than that of qi deficiency, yin deficiency syndrome; GP regimen in chemotherapy toxicity aspects, qi deficiency, yin deficien-cy syndrome compared with phlegm wet heavy card. Conclusion: the GP program has a certain effect on the various TCM syndrome types inthe middle and late stage of NSCLC, which has a more significant effect on phlegm dampness syndrome, and the toxic and side effects are rela-tively small.