特发性快动眼期睡眠行为异常非运动障碍的特点

Characteristics of non-dyskinesias in idiopathic REM sleep disorder

目的通过分析快动眼期睡眠行为异常(idiopathic REM sleep disorder,iRBD)患者是否存在嗅觉减退、睡眠障碍、焦虑抑郁,来探讨iRBD患者的非运动障碍特点。方法收集我院2014年1月至2016年1月iRBD患者48例及健康对照组53例,分别对两组人群进行睡眠指标、嗅觉功能、焦虑抑郁量表以及血清中IL-6、TNF-α浓度的检测。结果 iRBD组与健康对照组比较,其总睡眠时间、睡眠效率明显降低(P<0.05);睡眠潜伏期、觉醒指数、快动眼睡眠潜伏期明显增高(P<0.05);嗅觉减退明显增多(P<0.01);焦虑抑郁评分明显增高(P<0.05);但两组人群血清中IL-6及TNF-α浓度差异没有统计学意义(P>0.05)。结论 iRBD与帕金森病有类似的非运动障碍特点,早期干预iRBD人群有利于帕金森病患者的预防和治疗。

Objective To study the characteristics of non-dyskinesias in （idiopathic REM sleep disorder, iRBD） patients by examining the possible symptoms of hyposmia, sleep disorders, anxiety and depression. Methods Forty-eight iRBD patients and 53 healthy people recruited from our hospital between Jan 2014 and Jan 2016 were studied as treatment and control groups. The subjects of the 2 groups were evaluated by factors including sleep indicators, olfactory function, anxiety and depression scale, and blood serum concentrations of interleukin-6 （IL-6） and tumor necrosis factor-alpha （TNF-α）. Results Compared with control group, total sleep time and sleep efficiency were significantly reduced in treatment group （P 〈 0. 05）. Also, sleep latency, awakening index and rapid eye movement （REM） sleep latency were significantly increased （P 〈 0.05 ）, along with more severe hyposmia and higher score of anxiety and depression in the treatment than control group （ P 〈 0. 05 ）. But there were no significant differences in the serum levels of IL-6 and TNF-αbetween the 2 groups （ P 〉 0. 05 ）. Conclusion Patients with iRBD or Parkinson＇ s disease （PD） share similar symptoms of non-dyskinesias. Early intervention in iRBD patients will be of benefit to prevent and treat patients with PD.