摘要
Four novel 4-arylpolyhydroquinoline derivatives（1~4） were synthesized and characterized via IR,~1H NMR,H RMS,and single-crystal X-ray crystallography. It crystallizes in triclinic,space group P1 with a = 7.382（5）,b = 10.766（7）,c = 11.583（8） ？,α = 66.077（10）,β = 77.461（10）,γ = 82.590（11）o,V = 820.6（10） ？~3,Z = 2,F（000） = 332,Dc = 1.260 Mg/m^3,Mr = 311.37 and μ = 0.085 mm-1. In addition,the antitumor effects of compounds 1~4 were studied on three human tumor cells（NCI-H1688,AGS and 95-D）. The results showed that compared with compounds 1 and 2,compounds 3 and 4 displayed efficient antitumor activity.
Four novel 4-arylpolyhydroquinoline derivatives（1~4） were synthesized and characterized via IR,~1H NMR,H RMS,and single-crystal X-ray crystallography. It crystallizes in triclinic,space group P1 with a = 7.382（5）,b = 10.766（7）,c = 11.583（8） ？,α = 66.077（10）,β = 77.461（10）,γ = 82.590（11）o,V = 820.6（10） ？~3,Z = 2,F（000） = 332,Dc = 1.260 Mg/m^3,Mr = 311.37 and μ = 0.085 mm-1. In addition,the antitumor effects of compounds 1~4 were studied on three human tumor cells（NCI-H1688,AGS and 95-D）. The results showed that compared with compounds 1 and 2,compounds 3 and 4 displayed efficient antitumor activity.
