双歧杆菌三联活菌联合莫沙必利对功能性消化不良患者的疗效及对血液流变学和血清胃肠激素水平的影响

Effect of triple viable bifidobacterium combined with mosapride on hemorheology and serum gastrointestinal hormone levels in patients with functional dyspepsia

目的:观察双歧杆菌三联活菌联合莫沙必利对功能性消化不良(FD)患者的疗效及对血液流变学和血清胃肠激素水平的影响。方法:将127例FD患者随机分为观察组(65例)和对照组(62例)。对照组给予莫沙必利治疗,观察组在对照组的基础上联合双歧杆菌三联活菌。治疗2月,观察两组疗效及血液流变学指标[血液全血黏度(高切、低切)、血浆粘度]和血清胃肠激素(MTL、NPY、VIP)水平的变化。结果:治疗前,两组血液全血黏度(高切、低切)、血浆粘度水比较差异无统计学意义(P>0.05);治疗后,观察组血液全血黏度(高切、低切)、血浆粘度水平较治疗前均明显下降(P<0.05)而对照组无明显变化(P>0.05),两组同期比较差异有统计学意义(P<0.05)。治疗前,两组MTL、NPY、VIP水比较差异无统计学意义(P>0.05);治疗后,两组MTL、NPY均较本组治疗前明显上升而VIP明显下降(P<0.05),且观察组变化幅度大于对照组,同期比较差异均有统计学意义(P<0.05)。结论:双歧杆菌三联活菌联合莫沙必利治疗FD临床疗效优于单用莫沙必利,可能与联合应用对血液流变学及血清MTL、NPY、VIP的调节作用更大有关。

Objective：To observe the effect of triple viable bifidobacterium combined with mosapride on hemorheology and serum gastrointestinal hormone levels in patients with functional dyspepsia （FD）.Methods：A total of 127 patients with FD were randomly divided into the observation group （67cases）and the control group （62 cases）.The control group was given mo-sapride,the observation group was given triple viable bifidobacterium on the base of the control group.For 2 months,to ob-serve the efficacy and changes of hemorheology [the whole blood viscosity （high and low shear）,plasma viscosity]and serum gastrointestinal hormone levels （MTL,NPY,VIP）.Results：After treatment,the observation group of the whole blood viscos-ity （high and low shear）,plasma viscosity were decreased significantly （P 〈0.05）,but those of the control group showed no significantly difference compared with before （P 〉 0.05 ）.There was significantly difference between the two groups （P 〈0.05）;After treatment,serum MTL,NPY were increased and VIP was increased in both groups （P 〈0.05）,and all indexes of the observation group were improved more significant than those of the control group （P 〈0.05）.Conclusions：Efficacy of triple viable bifidobacterium combined with mosapride is more better than single mosapride in the treatment of FD.It may be related to its effects on hemorheology and gastrointestinal hormone.