别嘌呤醇联合痛风定胶囊对痛风患者炎症因子、肝肾功能及相关指标的影响研究

Effect of allopurinol combined with Tongfengding capsule on inflammatory factors,hepatorenal functions and related indicators in gouty patients

目的:探究别嘌呤醇联合痛风定胶囊对痛风患者炎症因子、肝肾功能及痛风相关指标的影响。方法:选取四川省德阳市人民医院收治的180例痛风患者,按随机数字表法将痛风患者分为观察组和对照组,每组各90例,对照组给予常规治疗和别嘌呤醇治疗,观察组在给予常规治疗基础上给予别嘌呤醇和痛风定胶囊治疗,治疗前和治疗后检测痛风患者炎症因子、肝肾功能及痛风相关指标变化情况。结果:两组痛风患者治疗前炎症因子、肝肾功能及痛风相关指标比较差异无统计学意义(P>0.05);与治疗前相比,观察组治疗后的炎症因子(IL-6、IL-8、TNF-α和CRP)、肝肾功能(ALT、AST、BUN和Cr)及痛风相关指标(ESR、UA、24h尿蛋白和XOD)显著降低,差异具有统计学意义(P<0.05);对照组经治疗后的炎症因子、肝肾功能及痛风相关指标显著降低,差异有统计学意义(P<0.05);观察组治疗后的炎症因子、肝肾功能及痛风相关指标比对照组治疗后降低显著,组间比较差异有统计学意义(P<0.05);结论:别嘌呤醇联合痛风定胶囊的治疗能够改善痛风患者炎症因子、肝肾功能及痛风相关指标水平,为痛风患者的临床治疗提供帮助。

Objective：To observe the effects of allopurinol combined with Tongfengding capsule on inflammatory fac-tors,hepatorenal functions and the related indicators in gouty patients,for helping clinical treatment of gouty patients.Meth-ods：A total of 180 gouty patients in our hospital were selected and randomly divided into observation group and control group, 90 cases in each group.Control group was treated with conventional therapy and allopurinol therapy,observation group was treated with allopurinol combined with Tongfengding capsule based on conventional therapy,the changes of inflammatory fac-tors,hepatorenal functions and the related indicators were detected before and after treatment.Results：The difference of in-flammatory factors,hepatorenal functions and the related indicators in the two groups before treatment was not statistically significant （P 〉0.05 ）.Inflammatory factors （IL-6,IL-8,TNF-α and CRP）,hepatorenal functions （ALT,AST,BUN and Cr）and gout related indicators （ESR,UA,24 h urine protein and XOD）in observation group after treatment significantly de-creased compared with that before treatment.Inflammatory factors,hepatorenal functions and gout related indicators in control＆nbsp;group after treatment significantly decreased （P 〈0.05）.Inflammatory factors,hepatorenal functions and gout related indica-tors in observation group after treatment decreased more significantly than that in control group （P 〈0.05）.Conclusions：Allo-purinol combined with Tongfengding capsule could improve inflammatory factors,hepatorenal functions and the related indica-tors in gouty patients,and help clinical treatment of gouty patients.