维胺酯胶囊联合消银颗粒对银屑病患者血清VEGF、TNF、NO、白细胞介素及T细胞亚群的影响

Effect of viaminate capsule combined with Xiaoyin particles on serum VEGF,TNF,NO,interleukins and T lymphocyte subsets in patients with psoriasis

目的：探讨维胺酯胶囊联合消银颗粒对银屑病患者血清血管内皮生长因子（vascular endothelial growth factor,VEGF）、肿瘤坏死因子（tumor necrosis factor,TNF）、一氧化氮（NO）、白细胞介素及 T细胞亚群的影响.方法：选择2014年5月~2016年5月我院收治的90例银屑病患者,随机分为对照组和试验组,各45例.对照组患者给予维胺酯胶囊治疗,试验组患者给予维胺酯胶囊联合消银颗粒治疗,两组患者均给予治疗3个月.检测并比较两组患者治疗前后血清 VEGF、TNF-α、NO、白细胞介素-6（interleukin-6,IL-6）白细胞介素-8（interleukin-8,IL-8）、白细胞介素-1β（interleukin-1β,IL-1β）水平以及外周血 CD4＋、CD8＋细胞所占的比值.结果：治疗后,两组以上各血清指标水平均明显低于治疗前,差异均具有统计学意义（P ＜0．05）,同时试验组以上各血清指标水平均明显低于对照组,差异具有统计学意义（P ＜0．05）.治疗后,两组外周血中 CD4＋、CD4＋/CD8＋水平均明显高于治疗前,同时试验组外周血中 CD4＋、CD4＋/CD8＋水平均明显高于对照组,差异具有统计学意义（P ＜0．05）.治疗后,两组外周血中 CD8＋水平均明显低于治疗前,差异具有统计学意义（P ＜0．05）,但两组治疗后外周血中 CD8＋水平比较差异无统计学意义（P ＞0．05）.结论：维胺酯胶囊联合消银颗粒能够明显降低银屑病患者血清 VEGF、TNF-α、NO、IL-6、IL-8及 IL-1β水平,改善 T 淋巴细胞亚群水平,提高患者机体免疫力,值得在临床上推广应用.

Objective：To study the effect of viaminate capsule combined with Xiaoyin particles on serum VEGF,TNF, NO,interleukins and T lymphocyte subsets in patients with psoriasis.Methods A total of 90 patients with psoriasis in our hos-pital from May 2014 to May 201 6 were enrolled in this study.The subjects were divided into the control group （n =45）and the＆nbsp;treatment group （n =46）randomly.The control group were treated with viaminate capsule,the treatment group were treated with viaminate capsule combined with Xiaoyin particles.The two groups were treated for 3 months.The serum VEGF,TNF-α,NO,IL-6,IL-8,IL-1βlevels and peripheral blood CD4 ＋ and CD8 ＋ cells of the two groups before and after treatment were compared.Results There were no significantly differences of the serum VEGF,TNF-α,NO,Interleukins （IL-6,IL-8,IL-1β） levels and peripheral blood CD4 ＋ ,CD8 ＋ and CD4 ＋/CD8 ＋ cells of the two groups before treatment （P 〉 0.05 ）.The serum VEGF,TNF-α,NO,Interleukins （IL-6,IL-8,IL-1β）levels of the two groups after treatment were significantly lower than before treatment （P 〈0.05）,and that of treatment group were significantly lower than the control group （P 〈0.05）.The pe-ripheral blood CD4 ＋ and CD4 ＋/CD8 ＋ cells of the two groups after treatment were significantly higher than before treatment （P 〈0.05）,CD8 ＋ cells of the two groups after treatment were significantly lower than before treatment （P 〈0.05）,the pe-ripheral blood CD4 ＋ and CD4 ＋/CD8 ＋ cells of the treatment group after treatment were significantly higher than that of the control group （P 〈0.05）,but there was no significantly differences in the peripheral blood CD8 ＋ cells of the two groups after treatment （P 〉0.05）.Conclusions Viaminate capsule combined with Xiaoyin particles can significantly reduce the serum VEGF, TNF-α,NO,IL-6,IL-8 and IL-1βlevels,improve the T lymphocyte subgroup levels of the patients with psoriasis,and it was worthy clinical application.