左氧氟沙星对肺结核患者肺表面活性物质、趋化因子及白介素的影响

Influence of levofloxacin on pulmonary surfactant,chemotactic factors and interleukins of patients with pulmonary tuberculosis

目的：研究及观察左氧氟沙星对肺结核患者肺表面活性物质、趋化因子及白介素的影响程度。方法：将68例2013年2月～2015年2月期间本院收治的肺结核患者根据随机分配的方式分为两组，对照组的34例肺结核患者遵照常规肺结核治疗方案进行治疗，观察组的34例肺结核患者遵照常规治疗加左氧氟沙星，然后将两组患者治疗前和治疗后1个月、3个月及6个月的血清肺表面活性物质、趋化因子及白介素指标进行比较。结果：治疗前两组患者的血清肺表面活性物质、趋化因子及白介素指标比较（均P〉0．05），而观察组治疗后1个月、3个月及6个月上述三方面血清表达水平均改善更为明显，且均好于对照组和治疗前（均P〈0．05）。结论：左氧氟沙星可显著改善肺结核患者的肺表面活性物质、趋化因子及白介素血清表达水平，对于此类患者的炎性趋化及肺部状态具有积极的临床改善作用。

Objective： To study the influence degree of levofloxacin on the pulmonary surfactant, chemotactic factors and interleukins of patients with pulmonary tuberculosis. Methods： A total of 68 patients with pulmonary tuberculosis received treatment in our hospital during the period of February 2013 to February 2015 were divided into two groups according to the method of random allocation,and 34 patients in control group were treated with conventional pulmonary tuberculosis treatment program, 34 patients in observation group were treated with levofloxacin on the basis of conventional treatment, then the serum pulmonary surfactant,chemotactic factors and interleukins indexes of patients in two groups before the treatment and at 1st month,3rd month and 6th month after the treatment were compared. Results： The difference in serum pulmonary surfactant, chemotaetie factors and interleukins indexes of two groups before the treatment were significant （all P〉0.05）,while the three items of observation group at 1st month, 3rd month and 6th month after the treatment were more effectively improved,and they were all better than the detection levels of control group and before the treatment （all P〈0.05）. Conclusions： The levofloxacin can significantly improve the serum expression levels of pulmonary surfactant, chemotactic factors and interleukins of patients with pulmonary tuberculosis, so it has active clinical improvement effects for the inflammatory chemotactie state and pulmonary state of the patients.