帕金森患者血清同型半胱氨酸代谢、氧化应激程度与周围神经损害的相关性

Correlation of serum homocysteine metabolism and oxidative stress level with peripheral nerve damage in patients with Parkinson's disease

目的:分析帕金森患者血清同型半胱氨酸代谢、氧化应激程度与周围神经损害的相关性。方法:58例帕金森病患者及67例正常人纳入本次研究,检测两组研究对象的血浆同型半胱氨酸(Hcy)及超氧化物歧化酶(SOD)、GSH、丙二醛(MDA)等氧化应激指标水平,测定腓总神经的传导速度(MCV)、潜伏期(LP)、波幅(Amp)。结果:观察组患者的血清Hcy水平高于对照组,叶酸及维生素B6水平低于对照组;血清氧化指标LHP、H_2O_2、AOPP、MDA水平高于对照组,抗氧化指标SOD T、SOD Mn、SOD Cu-Zn、GSH-PX、T-AOC、CAT水平低于对照组;腓总神经MCV、Amp值低于对照组,LP值高于对照组。帕金森患者的周围神经损害参数值与血清Hcy代谢指标及氧化应激指标水平存在直接相关关系。结论:帕金森患者的周围神经损害与高Hcy血症及氧化应激紊乱相关,干预患者血清Hcy及氧化应激指标水平有望成为帕金森病治疗的新途径。

Objective：To analyze the correlation of serum homocysteine metabolism and oxidative stress level with pe-ripheral nerve damage in patients with Parkinson＇s disease.Methods：A total of 58 patients with Parkinson＇s disease and 67 nor-mal human beings were included in the study,levels of plasma homocysteine （Hcy）as well as superoxide dismutase （SOD）, GSH,malondialdehyde （MDA）and other oxidative stress indexes were detected,and common peroneal nerve motor conduc-tion velocity （MCV）,latent period （LP）and amplitude （Amp）were determined.Results：Serum Hcy level of observation group was higher than that of control group while folic acid and vitamin B6 levels were lower than those of control group;ser-um oxidative indexes LHP,H2O2,AOPP and MDA levels were higher than those of control group while antioxidant indexes SOD T,SOD Mn,SOD Cu-Zn,GSH-PX,T-AOC and CAT levels were lower than those of control group;common peroneal nerve MCV and Amp values were lower than those of control group while LP value was higher than that of control group.Pe-ripheral nerve damage parameter values in patients with Parkinson＇s disease were directly correlated with serum levels of Hcy metabolism indexes and oxidative stress indexes.Conclusions：Peripheral nerve damage in patients with Parkinson＇s disease is＆nbsp;associated with hyperhomocysteinemia and oxidative stress disorder,and intervention in serum levels of Hcy and oxidative stress indexes is expected to become a new way for treatment of Parkinson＇s disease.