长期饮酒对下腹部手术患者术中麻醉抗药及术后认知功能的影响

Effect of long-term drinking on intraoperative anesthetic drug resistance and postoperative cognitive function in patients with lower abdominal surgery

目的:发现长期饮酒对下腹部手术患者术中麻醉抗药及术后认知功能的影响。方法:118例接受下腹部手术的患者纳入研究,分为长期饮酒组43例,对照组75例。对比两组患者的围麻醉期血流动力学指标、应激指标,术后血清氨基酸递质、神经功能指标含量差异。结果:长期饮酒组患者的划皮时(T2)、切口缝合时(T3)血流动力学指标CO、VO2值大于对照组患者,SV值小于对照组患者,应激指标Glu、Cor、AngⅡ、E、NE含量高于对照组患者;长期饮酒组患者的术后血清Glu、Asp、Gly、GABA、Ala、Tau含量高于对照组患者,NSE、S100β、MMP-9含量高于对照组患者,BDNF、ADP含量低于对照组患者。结论:长期饮酒可增加下腹部手术患者的麻醉抗药性,增加术后认知功能障碍发生率。

Objective：To find the effect of long-term drinking on intraoperative anesthetic drug resistance and postoper-ative cognitive function in patients with lower abdominal surgery.Methods：A total of 1 18 patients with lower abdominal sur-gery were included in the study and divided into long-term drinking group with 43 cases and control group with 75 cases.Differ-ences in peri-anesthetic hemodynamic indexes and stress indexes as well as postoperative serum amino acid neurotransmitters and nerve function indexes were compared between two groups.Results：Hemodynamic indexes CO and VO2 values of long-term drinking group at skin incision （T2）and at incision suture （T3）were greater than those of control group,SV value was less than that of control group,and stress indexes Glu,Cor,AngⅡ,E and NE levels were higher than those of control group;postoperative serum Glu,Asp,Gly,GABA,Ala and Tau levels of long-term drinking group were higher than those of control group,NSE,S100βand MMP-9 levels were higher than those of control group,and BDNF and ADP levels were lower than those of control group.Conclusions：Long-term drinking can increase the anesthetic drug resistance in patients with lower ab-dominal surgery and increase the incidence of postoperative cognitive dysfunction.