EGFR-TKI联合^(125)I粒子植入治疗对ⅢB～Ⅳ期肺癌组织的杀伤效应评估

Killing effect of EGFR-TKI combined with ^(125)I seed implantation therapy on ⅢB～Ⅳ stage lung cancer tissue

目的:分析EGFR-TKI联合^(125)I粒子植入治疗对ⅢB~Ⅳ期肺癌组织的杀伤效应。方法:78例ⅢB~Ⅳ期肺癌患者随机分为观察组及对照组各39例,对照组患者接受EGFR-TKI治疗,观察组患者接受EGFR-TKI联合^(125)I粒子植入治疗。对比两组患者的治疗1个月后肺组织凋亡基因、侵袭基因、自噬基因表达量差异。结果:观察组患者的治疗1个月后肺组织凋亡基因PDCD5、bax、bcl-xS mRNA表达量高于对照组患者(P<0.05),Bag-1、survivin、bcl-xL mRNA表达量低于对照组患者(P<0.05);侵袭基因CD147、EGFR、DDX17 mRNA表达量低于对照组患者(P<0.05),Bin1、E-cadherin、Ovol2mRNA表达量高于对照组患者(P<0.05);自噬基因ARHI、Beclin1、Atg5、LC3B、pULK、PI3KC3mRNA表达量均高于对照组患者(P<0.05)。结论:EGFR-TKI联合^(125)I粒子植入治疗可增强对ⅢB~Ⅳ期肺癌患者的肿瘤杀伤作用,有助于整体病情的优化及生存时间的延长。

Objective：To analyze the killing effects of EGFR-TKI combined with 125^Iseed implantation therapy onⅢB-Ⅳ stage lung cancer tissue.Methods：A total of 78 patients withⅢB-Ⅳstage lung cancer were randomly divided into observation group and control group（n=39）,control group received EGFR-TKI treatment and observation group received EGFR-TKI combined with 125^Iseed implantation therapy.Differences in apoptosis gene,invasion gene and autophagy gene expression in lung tissue were compared between two groups after 1month of treatment.Results：Apoptosis genes PDCD5,bax and bcl-xS mRNA expression levels in lung tissue of observation group after 1month of treatment were higher than those of control group while Bag-1,survivin and bcl-xL mRNA expression levels were lower than those of control group;invasion genes CD147,EGFR and DDX17 mRNA expression levels were lower than those of control group while Bin1,E-cadherin and Ovol2 mRNA expression levels were higher than those of control group;autophagy genes ARHI,Beclin1,Atg5,LC3 B,pULK and PI3KC3 mRNA expression levels were higher than those of control group.Conclusion：EGFR-TKI combined with 125^Iseed implantation therapy can enhance the tumor killing effect on patients with ⅢB-Ⅳ stage lung cancer,and contribute to the optimization of overall condition and the extension of survival time.