胆舒胶囊联合喜炎平治疗急性胆囊炎的机制研究

Mechanism of Danshu capsules combined with Xiyanping for acute cholecystitis

目的:研究胆舒胶囊联合喜炎平治疗急性胆囊炎的机制,为急性胆囊炎患者的临床治疗提供更好的帮助。方法:选取门诊治疗的180例急性胆囊炎患者,随机将患者分为联合治疗组和对照组,每组90例,对照组患者采用常规治疗,联合治疗组在常规治疗基础上给予胆舒胶囊联合喜炎平的治疗。治疗前后检测并分析各组患者免疫细胞、胆囊炎相关指标、炎症因子和凝血功能相关指标。结果:与治疗前相比,两组患者经治疗后凝血功能指标[凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)]、CD8^+、胆囊炎相关指标[总胆红素、淀粉酶以及降钙素原(PCT)]、炎症因子[超敏C-反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素-10(IL-10)]显著降低,血清前白蛋白(PA)、免疫细胞(CD3^+、CD4^+和CD4^+/CD8^+)显著升高,差异存在统计学意义(P<0.05);凝血酶时间(TT)和纤维蛋白原(FIB)水平变化不明显(P>0.05)。与治疗后对照组相比,治疗后的联合治疗组凝血功能指标(PT和APPT)、CD8^+、胆囊炎相关指标(总胆红素、淀粉酶以及PCT)、炎症因子(hs-CRP、TNF-α、IL-6和IL-10)显著降低,PA、免疫细胞(CD3^+、CD4^+和CD4^+/CD8^+)显著升高,差异存在统计学意义(P<0.05);TT以及FIB水平变化不明显(P>0.05)。结论:胆舒胶囊联合喜炎平能够显著改善急性胆囊炎患者免疫细胞、胆囊炎相关指标、炎症因子和凝血功能相关指标,对急性胆囊炎患者的治疗具有积极的临床意义。

Objective：To observe the mechanism of Danshu capsules combined with Xiyanping for acute cholecystitis treatment in order to find better treatments for acute cholecystitis.Methods：A total of 180 patients with acute cholecystitis were selected and randomly divided into groups：the observation group（90people）and the control group（90people）.The patient in the control group were treated with conventional therapy and the patients in the observation group were treated with Danshu capsules combined with Xiyanping on the basis of conventional therapy.Immunological cell,cholecystitis related factors,inflammatory factors,and the coagulation function related factors were detected and analyzed before and after treatment.Results：Coagulation function related factors（PT and APTT）,CD8^＋,cholecystitis related factors（total bilirubin,amylase and PCT）,inflammatory factor（hs-CRP、TNF-α、IL-6和IL-10）in both groups after treatment significantly decreased.PA,immunological cell（CD3^＋,CD4^＋and CD4^＋/CD8^＋）significantly increased compared with that before treatment.The difference before and after treatment was considered to be statistically significant（P〈0.05）.PP and the changes of FIB were not statistically significant（P〈0.05）.Coagulation function related factors（PT and APTT）,CD8^＋,cholecystitis related factors（total bilirubin,amylase and PCT）,and inflammatory factor（hs-CRP、TNF-α、IL-6和IL-10）in observation group after treatment decreased more significantly than that in control group,it was considered to be statistically significant（P〈0.05）.Conclusion：Danshu capsules combined with Xiyanping can perfect effectively immunological cell,cholecystitis related factors,inflammatory factors and coagulation function related factors on patients with acute cholecystitis,it has important clinical significance for acute cholecystitis.