复方苦参注射液联合平消片治疗乳腺癌的机制研究

Mechanism of Compound Radix Sophorae Flavescentis Injection combined with Xiaoyao pill treating breast cancer

目的:探究复方苦参注射液联合平消片的治疗对乳腺癌患者肿瘤标志物、细胞因子和T淋巴细胞亚群水平的影响,为乳腺癌患者的辅助治疗提供理论依据。方法:选取本院收治的100例乳腺癌患者,将患者按随机数字表法分为观察组和对照组,每组各50例,对照组患者采用AC序贯T化疗方案,观察组在AC序贯T化疗的基础上给予复方苦参注射液联合平消片的治疗。治疗前后分别检测各组乳腺癌患者肿瘤标志物、细胞因子和T淋巴细胞亚群水平。结果:治疗前两组乳腺癌患者乳腺癌肿瘤标志物水平、细胞因子水平和T淋巴细胞亚群水平的比较差异无统计学意义(P>0.05)。与治疗前相比,观察组和对照组乳腺癌患者经相关治疗后肿瘤标志物(CA153、CEA和CA125)、细胞因子(IL-4、IL-6和IL-10)降低、IFN-γ及IL-2升高,T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)升高,CD8^+降低,差异存在统计学意义(P<0.05)。与治疗后对照组相比,观察组经治疗后肿瘤标志物(CA153、CEA和CA125)、CD8^+和细胞因子(IL-4、IL-6和IL-10)降低、IFN-γ和IL-2升高,T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)升高,CD8^+降低,组间比较差异存在统计学意义(P<0.05)。结论:复方苦参注射液联合平消片的治疗可降低乳腺癌患者的肿瘤标志物水平,提高细胞因子和T淋巴细胞亚群水平,对乳腺癌患者的综合治疗具有积极的临床意义。

Objective：To investigate the influence of Compound Radix Sophorae Flavescentis Injection and Xiaoyao pill combined therapy on tumor markers,cytokines and lymphocyte subpopulations of breast cancer patients,thus provide relevant assistance on clinical therapy for breast cancer patients.Methods：A total of 170 cases of breast cancer patients treated in our hospital were selected and divided to be the observe group and control group at random,with 85 cases in each group.For patients in control group,AC chemotherapeutic project was utilized,and for patients in observe group,Compound Radix Sophorae Flavescentis Injection and Xiaoyao pill combined therapy were provided on the basis of AC chemotherapy.Tumor markers,cytokines and lymphocyte subpopulations of breast cancer patients in each group were detected before and after therapy.Re-sults：Comparison of tumor markers,cytokines and lymphocyte subpopulations levels between the two groups of breast cancer patients before therapy showed no statistical significance（P〈0.05）.Compared with prior therapy,the tumor markers（CA153,CEA and CYRA21-1）,CD8^＋and cytokines（IL-4,IL-6and IL-10）on both the two groups of breast cancer patients were dramatically decreased,while lymphocyte subpopulations（CD3^＋,CD4^＋,CD4^＋/CD8^＋）,IFN-γand IL-2were significantly increased,the differences showed statistical significance（P〈0.05）.Conclusion：Compound Radix Sophorae Flavescentis Injection and Xiaoyao pill combined therapy significantly improved the tumor markers,cytokines and lymphocyte subpopulations of the breast cancer patients.It is of vital clinical significance for treatment on breast cancer patients.