系统家庭治疗对精神分裂症患者康复的影响

Effects of systemic family therapy on the rehabilitation in patients with schizophrenia

目的：探讨系统家庭治疗对精神分裂症患者康复的影响。方法：选取2011年2月-2014年2月本院收治的精神分裂症患者86例为研究对象,随机分为观察组（n=43）和对照组（n=43）,并设健康体检者43例为健康组进行对比研究。对照组服用单剂量利培酮,进行一般电话随访,观察组在对照组基础上进行系统家庭治疗。采集健康组及精神分裂症患者治疗前及治疗3个月后清晨空腹静脉血,测定脑源性神经生长因子（BDNF）、神经生长因子（NGF）、胶质纤维酸性蛋白因子（GFAP）及白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）,治疗6个月后采用症状自评量表（SCL-90）对观察组和对照组进行心理状态评价。结果：观察组和对照组治疗前后血清BDNF、GFAP水平高于健康组,NGF水平低于健康组（P〈0.05）,治疗3个月后观察组和对照组BDNF、GFAP水平高于治疗前（P〈0.05）,NGF水平低于治疗前,但两组治疗后各蛋白因子比较无统计学意义（P〉0.05）;观察组和对照组治疗前后血清IL-6、TNF-α水平高于健康组（P〈0.05）,治疗3个月后观察组和对照组IL-6、TNF-α水平低于治疗前（P〈0.05）,但两组治疗后各蛋白因子比较无统计学意义（P〉0.05）;观察组治疗6个月后SCL-90量表各项评分较治疗前降低（P〈0.05）,而对照组上述指标无明显变化（P〉0.05）。结论：系统家庭治疗为精神分裂症患者康复的有效辅助治疗方法,能有效改善患者心理健康状况,值得临床推广。

Objective：To explore the effects of systemic family therapy on the rehabilitation in patients with schizophrenia.Methods：A total of 86 patients with schizophrenia who were admitted in our hospital were included in the study and randomized into the observation group and the control group.A total of 43 healthy individuals for physical examinations were served as the healthy group.The patients in the control group were given risperidone in a single dose,and telephone follow-up.On this basis,the patients in the observation group were given systemic family therapy.The morning fasting venous blood before treatment and 3months after treatment in the healthy group and patients with schizophrenia was collected.BDNF,NGF,GFAP,IL-6,and TNF-αwere detected.After 6-month treatment,SCL-90 was used to evaluate the psychological state.Results：The serum BDNF and GFAP levels before and after treatment in the observation group and the control group were signif-icantly higher than those in the healthy group,while NGF level was significantly lower than that in the healthy group（P〈0.05）.After 3-month treatment,BDNF and GFAP levels in the observation group and the control group were significantly increased when compared with before treatment（P〈0.05）,but the comparison of proten factors between the two groups was not statistically significant（P〉0.05）.The serum IL-6and TNF-αlevels before and after treatment in the observation group and the control group were significantly lower than those in the healthy group（P〈0.05）.After 3-month treatment,IL-6and TNF-αlevels in the observation group and the control group were significantly reduced when compared with before treatment,but the comparison of protein factors between the two groups was not statistically significant（P〈0.05）.After 6-month treatment,the scores of somatization,interpersonal relationship,fear,anxiety,hostility,paranoid,depression,obsession,and mental disorder in the observation group were significantly reduced when compared with before treatment（P〈0.05）,while the above indicators in the control group were not significantly changed（P〉0.05）.Conclusions：The systemic family therapy is an effective adjuvant method for the rehabilitation in patients with schizophrenia,and can effectively improve the mental health status;therefore,it deserves to be widely recommended in the clinic.