奥氮平联合无抽搐电休克治疗对精神分裂症患者细胞因子、sTNFRs及神经电生理特征的影响

Effect of olanzapine combined with modified electroconvulsive therapy on cytokines,sTNFRs and neural electrophysiological characteristics in patients with schizophrenia

目的：分析奥氮平联合无抽搐电休克治疗对精神分裂症患者细胞因子、可溶性肿瘤坏死因子受体（sTNFRs）及神经电生理特征的影响。方法：选择2013年3月-2016年3月本院收治的精神分裂症患者并随机分为两组（n=51）,观察组接受奥氮平联合无抽搐电休克治疗,对照组接受奥氮平治疗。治疗6周后,比较两组的血清sTNFR、急性时相反应蛋白、脑功能指标含量以及神经电生理特征。结果：治疗6周后,观察组患者血清中sTNFRs、血清C反应蛋白（CRP）、铜蓝蛋白（CER）、α1-酸性糖蛋白（AAG）含量低于对照组患者,转铁蛋白（TRF）含量高于对照组患者;血清脑功能指标神经生长因子（NGF）、脑源性神经营养因子（BDNF）含量高于对照组患者,胶质纤维酸性蛋白（GFAP）、S100B蛋白（S100B）、神经元特异性烯醇化酶（NSE）、同型半胱氨酸（Hcy）含量低于对照组患者;神经电生理指标P300、后正电位（LPP）、错误相关负电位（ERN）波幅高于对照组患者,LPP波幅低于对照组患者,差异均具有统计学意义（P〈0.05）。结论：奥氮平联合无抽搐电休克治疗可优化精神分裂症病情,降低神经电生理异常程度,有助于疾病治疗结局的改善。

Objective：To analyze the effects of olanzapine combined with modified electroconvulsive therapy on cytokines,sTNFRs and neural electrophysiological characteristics in patients with schizophrenia.Methods：Patients with schizophrenia treated in our hospital between March 2013 and March 2016 were selected and randomly divided into two groups（n=51）,the observation group received olanzapine combined with modified electroconvulsive therapy,and the control group received olanzapine therapy.After 6weeks of treatment,serum levels of soluble tumor necrosis factor receptor（sTNFR）,acute phase reaction proteins and brain function indexes as well as the neural electrophysiological characteristics were compared between the two groups.Results：After 6 weeks of treatment,serum sTNFRs,CRP,CER and AAG content of observation group were lower than those of control group while TRF content was higher than that of control group;serum brain function indexes NGF and BDNF content were higher than those of control group while GFAP,S100 B,NSE and Hcy content were low-er than those of control group;nerve electrophysiology indexes P300,LPP and ERN amplitude were higher than those of control group while LPP amplitude was lower than that of control group.Conclusion：Olanzapine combined with modified electroconvulsive therapy can optimize the condition of schizophrenia,reduce the degree of neural electrophysiological abnormalities and help to improve treatment outcome.