他汀类药物联合参麦注射液治疗脓毒症的机制研究

Study on the mechanism of statins combined with Shenmai injection in the treatment of sepsis

目的:探究他汀类药物联合参麦注射液治疗脓毒症的机制,为脓毒症的临床治疗提供帮助。方法:对我院160例脓毒症患者进行诊治研究,随机分为观察组和对照组,每组各80例,对照组给予常规治疗,观察组在常规治疗的基础上给予阿托伐他汀和参麦注射液的治疗,治疗前和治疗后3d检测患者免疫细胞、免疫因子和凝血功能相关指标的变化情况。结果:两组脓毒症患者治疗前血清相关免疫因子、免疫细胞、凝血功能相关指标比较,差异无统计学意义(P>0.05);与治疗前相比,观察组经过阿托伐他汀联合参麦注射液治疗后相关免疫因子TNF-α、IL-6、hs-CRP显著降低,免疫细胞CD4^+、NK显著升高,CD8^+显著降低,凝血功能相关指标PLT显著升高,PT、APTT、FIB显著降低,差异具有统计学意义(P<0.05);与常规治疗后的对照组相比,观察组经过联合治疗后相关免疫因子TNF-α、IL-6、hsCRP显著降低,相关免疫细胞CD4~^+、NK显著升高,CD8^+显著降低,凝血功能相关指标PLT显著升高,PT、APTT、FIB显著降低,差异具有统计学意义(P<0.05)。结论:阿托伐他汀联合参麦注射液治疗能够改善脓毒症患者免疫功能和凝血功能,为脓毒症患者的临床治疗提供帮助。

Objective：To explore the mechanism of statins combined with Shenmai injection in the treatment of sepsis,and to provide help for clinical treatment of sepsis.Methods：Study on the diagnosis and treatment of 160 patients with sepsis in our hospital were conducted.According to the random number table method,sepsis patients were divided into observation group and control group with 80 cases in each,the control group was given conventional treatment,the observation group was treated with atorvastatin and Shenmai injection on the basis of the control group,immune cells,immune factors and blood coagulation function related indexes were detected in patients before and 3days after treatment.Results：Before treatment,there was no significant difference in serum related immune factors,immune cells and blood coagulation function related indexes between the two groups（P〈0.05）;compared with before treatment,in the observation group after atorvastatin combined with Shenmai injection treatment,the related immune factors TNF-α,IL-6,hs-CRP significantly decreased,the immune cells CD4^＋and NK significantly increased while CD8^＋significantly decreased,and the blood coagulation function related indexes PLT significantly increased while PT,APTT and FIB significantly decreased,the differences existed statistical significance（P〈0.05）;compared with the control group after conventional treatment,in the observation group after combined treatment,the re-lated immune factors TNF-α,IL-6,hs-CRP significantly decreased,the related immune cells CD4^＋and NK significantly increased while CD8-＋significantly decreased,and the blood coagulation function related indexes PLT significantly increased while PT,APTT and FIB significantly decreased,the differences between the two groups existed statistical significance（P〈0.05）.Conclusion：Atorvastatin combined with Shenmai injection can improve the immune function and blood coagulation function in patients with sepsis,and provide help for clinical treatment of patients with sepsis.