阿尔兹海默症动物模型的研究进展

The Research Progress of Animal Model of Alzheimer's Disease

阿尔兹海默病(Alzheimer’s disease,AD),是一种中枢神经系统进行性退行性疾病。由于发病机制复杂,发病原因多样,制约了其动物模型研究的发展,本文将阿尔兹海默症动物模型分为转基因动物模型与非转基因动物模型,并具体介绍了APP转基因小鼠模型、APP/PSI双转基因小鼠模型、Tau/APP/PSI三转基因小鼠模型三种转基因动物模型,以及Aβ诱导的AD动物模型等六种非转基因动物模型。与此同时就其动物模型的优缺点进行了总结,并对未来发展趋势做出展望。

Alzheimer ’s disease is a kind of central nervous system neurodegenerative disease. Because of its complex pathogenesis and various etiology,restricting the development of animal models. In this paper,the animal model of alzheimer’s disease is divided into transgenic animal model and the non-transgenic animal models,and the author concretely introduces the APP transgenic mice model,APP / PSI transgenic mice model,Tau / APP / PSI transgenic mice model,and the AD animal models induced by Aβ,cholinergic nerve injury animal model and other. At the same time,the advantages and disadvantages of the animal models are summarized,and the future development trend is forecasted.