功能性消化不良动物造模方法分析

Analysis of Anim al Modeling Methods for Functional Dyspepsia

功能性消化不良(functional dyspepsia,FD)是目前临床常见疾病。为明确FD发病机制,需制备合适的动物模型。FD属于中医学"痞满"、"胃脘痛"、"嘈杂"范畴,是非器质性疾病,该病动物模型尚无统一标准。目前通常用脾虚证模型作为FD模型,但两者并不完全等同。笔者总结了目前常见的造模方法,并进行分析。

Functional dyspepsia （FD） is a common disease in clinics. It is necessary to establish suitable animal models for clarifying the pathogenesis of FD. FD belongs to ＂Piman＂ （abdominal disten- sion ）, ＂Weiwantong＂ （ epigastric pain）, ＂Caoza＂ （ epigastric upset） in Chinese medicine （CM）. It is inorganic disease but functional disease. There is no unified standard for FD animal models. Pi deficiency syndrome model is often used as FD animal model now, but they are not completely the same thing. Authors summarized and analyzed common methods for FD modeling.