智杞颗粒治疗儿童高铅血症和铅中毒有效性和安全性的Meta分析

Efficacy and safety of Zhi Qi Granules for Lead Poisoning in Child:A Meta-Analysis

目的:系统评价智杞颗粒治疗儿童高铅血症和铅中毒的有效性和安全性。方法:检索中国知网、万方数据库、维普期刊数据库、PubMed、EMbase、Cochrane Library,尽可能全面收集相关临床试验,由2名研究者按纳入与排除标准独立筛选文献、提取资料并进行质量评价后,使用Revman5.3软件对血铅水平变化情况和血铅复常率进行Meta分析,并对结果进行敏感性分析。结果:共纳入7项研究,包括1 772例受试者,其中试验组1 019例,对照组753例。Meta分析结果显示:智杞颗粒与空白对照组的血铅水平治疗前后变化情况比较,MD=37.81,95%CI(24.75,50.88),P<0.01,两组比较差异有统计学意义;与杞菊地黄丸对照组的血铅水平治疗前后变化情况比较,MD=52.02,95%CI(35.10,68.93),P<0.01两组比较差异有统计学意义;智杞颗粒与空白对照组的血铅复常率比较,RR=3.07,95%CI(1.73,5.45),P=0.000 1,差异有统计学意义;纳入研究对不良反应的发生情况进行观察,结果均未发现不良反应。结论:本次关于智杞颗粒治疗儿童高铅血症和铅中毒有效性和安全性的系统评价结果显示,智杞颗粒治疗儿童高铅血症、铅中毒,可降低患儿血铅水平,具有较好的血铅复常效果。本次安全性分析结果显示,在临床使用中未发现服用智杞颗粒导致的不良反应,提示本品临床应用较为安全。

OBJECTIVE To systematically review the efficacy and safety of ZhiQi Granules for Lead Poisoning.METHODSWe electronically searched PubMed,EMbase,The Cochrane Library,CNKI,WanFang Data and VIP databases for all related clinical trials.The data extraction and quality assessment of included studies were conducted by two reviewers independently.Then,meta-analysis was conducted using RevMan5.3 software.RESULTS 7 studies were included,involving 1 772 patients.Compared with the blank group,there were Statistically differences in blood lead level（MD=37.81,95%CI（24.75,50.88）,P〈0.01）and normalization rate of blood level（RR=3.07,95%CI（1.73,5.45）,P=0.0001）,P〈0.01）.Compared with Qi Ju Di Huang Wan,there was Statistically difference in blood lead level（MD=52.02,95%CI（35.10,68.93）,P〈0.00001）.CONCLUSION Zhi Qi granules can reduce and normalize the level of blood lead when treat lead poisoning in child,and has good safety when using in clinical.