治疗慢性便秘药物五羟色胺_4受体激动剂普卡比利

Serotonin 4 receptor agonist prucalopride against chronic constipation

目的:总结普卡比利的药理和临床疗效,以期为临床合理使用本品提供参考。方法:查阅近期国内外相关文献,对普卡比利的重要药理作用、疗效及不良反应进行归纳、总结。结果:普卡比利为一高度选择性五羟色胺4受体激动剂,能够改善患者的肠功能状况(如增加排便次数、提高患者的生活质量及满意程度等),该药最常见的不良反应为头痛、腹泻、恶心及腹痛等。结论:普卡比利对慢性便秘具有较好的治疗作用,患者容易耐受,不良反应轻微。

OBJECTIVE To summarize pharmacological effects and clinical efficacy of prucalopride,provide a reference for clinical medication.METHODS Main pharmacological effects,clinical efficacy and side effects of prucalopride were searched in literatures in domestic and foreign databases in the last years.RESULTS Prucalopride was a highly selective serotonin receptor agonist which could improve bowel functions,including number of bowel movements and a range of other constipation symptoms,as well as health-related quality of life and patient satisfaction.The most common adverse events were headache,diarrhoea,nausea,abdominal pain,etc.CONCLUSION Prucalopride can be used to treat chronic constipation and is generally well tolerated in patients.