左氧氟沙星致过敏性休克64例文献分析

Literature analysis on 64 cases of anaphylactic shock caused by levofloxacin

目的：探讨左氧氟沙星致过敏性休克的临床特点及相关因素,为安全用药提供参考。方法：对2006年至2015年国内公开报道的64例左氧氟沙星致过敏性休克病例报告进行统计分析。结果：64例休克患者年龄分布主要介于21-50岁（67.19%）,男性明显多于女性。用药途径以静脉滴注为主（92.19%）,给药剂量集中于200-400 mg（73.44%）。发生于30min以内的速发型过敏性休克占76.56%。休克患者恢复时间与用药类型没有关系,但与血压的高低有关。舒张压越低,恢复时间越长（rs=-0.389,P=0.003）。不同舒张压患者恢复时间的差异有统计学意义（H=11.151,P=0.004,0-20 mmHg组患者恢复时间明显长于21-40 mmHg组（Z=2.274,P=0.023）和41-60 mmHg组（Z=3.116,P=0.002）。结论：左氧氟沙星致过敏性休克日益多见,且速发型比例较高,应尽早发现及快速救治。

OBJECTIVE To discuss characteristics and correlation factors of anaphylactic shock induced by levofloxacin,and provide a reference for clinical safe drug use.METHODS Clinical data of shock induced by levofloxacin in64 cases publicly reported in China from2006 to 2015 were statistically analyzed.RESULTS A total of 64 cases of shock were mainly distributed in ages between 21 and 50 years old（67.19%）.More males were included than females.Administration route was dominated by intravenous drip（92.19%）,dose range was concentrated on 200-400 mg（73.44%）.Immediate anaphylactic shock within30 min accounted for 67.19%.Recovery time of shock patients was not related to type of used drug,but related to blood pressure.Lower diastolic blood pressure,longer recovery time（rs=-0.389,P=0.003）.There was statistical significance in the recovery time of patients with different diastolic pressures（H=11.151,P=0.004）.Recovery time of patients in0-20 mmHg group was significantly longer than that in21-40 mmHg group（Z=2.274,P=0.023）and 41-60 mmHg group（Z=3.116,P=0.002）.CONCLUSION Anaphylactic shock caused by levofloxacin is becoming more and more frequent,rate of the immediate type is higher,which should be observed and treated quickly.