M蛋白血症的皮肤表现

The Skin Manifestation of M-proteinemia

M蛋白是浆细胞或B淋巴细胞单克隆增殖所分泌的异常免疫球蛋白或其片段,血液中存在M蛋白即M蛋白血症,常见于多发性骨髓瘤、巨球蛋白血症、POEMS综合征、原发性系统性淀粉样变、Schnitzler综合征等。可见皮肤受累,部分皮损表现相对特异,为疾病诊断的重要线索。本文就伴皮肤损害的M蛋白血症相关性疾病做一综述,以期为M蛋白阳性的临床复杂性疾病的诊疗提供思路及线索。

M-protein refers to the monoclonal immunoglobnlin or fragment produced by abnormal monoclonal plasma cells or B cells. M-proteinemia refers to blood with M-protein. It is commonly found in multiple myeloma, macroglobulinemia, POEMS syndrome, primary systemic amyloidosis, Schnitzler syndrome, etc. Skin is usually involved. Some skin lesions are relative specific to this disease. Thus, presence of these skin lesions are crucial clues to the diagnosis. Skin disorders associated with M-proteinemia are reviewed here in order to provide clues and ideas for the diagnosis and the treatment of these complicated diseases.