广州市2009年报告发病的鼻咽癌患者生存率及其影响因素分析

Survival rate of patients with nasopharyngeal carcinoma reported in Guangzhou City in 2009 and its influencing factors

目的分析广州市鼻咽癌患者的生存状况,为预后评价和防治提供依据。方法对2009年广州市肿瘤登记处的1 291例鼻咽癌的生存情况随访截止日期为2014-12-31,数据应用SPSS19.0进行统计分析,寿命表法计算观察生存,Log-rank检验比较组间肿瘤生存率,Cox回归模型进行多因素分析。结果广州市鼻咽癌患者1年、3年、5年生存率分别为85.80%、68.80%、57.89%,单因素分析显示不同性别、不同年龄、不同临床分期、不同治疗方法对鼻咽癌预后有影响,Cox多因素分析显示性别(OR=0.804)、分期(OR=1.458)、年龄分组(OR=1.338)、治疗方式(OR=1.466)是独立预后危险因素。结论广州市鼻咽癌患者生存率略高于全国平均水平,但低于中国香港,鼻咽癌防治应提高早诊率和采取有效的治疗方法。

Objective To analyze the survival status of patients with nasopharyngeal carcinoma （ NC ） in Guangzhou City so as to provide evidence for its prognosis evaluation, prevention and control. Methods A total of 1,291 NC cases registered by Guangzhou Cancer Registry in 2009 were followed up for survival by December 31, 2014. The data collected were statistically analyzed by SPSS 19.0 software. The life table method was used to estimate the observed survival rate, log-rank test to compare the survival rates among different tumor groups, and Cox regression model to perform multi-factor analysis. Results The 1-, 3- and 5-year survival rates of the patients with NC in Guangzhou City were 85.80%, 68.80% and 57.89% respectively. Single factor analysis showed that gender, age, clinical stage and treatment method affected the prognosis of NC. Cox multifactor analysis revealed that gender （OR=0.804） , clinical stage （ OR= 1.458） , age （ OR= 1.338） and treatment method （ OR= 1.466） were independent prognostic risk factors. Conclusions The survival rates of the patients with NC in Guangzhou City are slightly higher than the national average levels but lower than those in Hong Kong. Prevention and control of NC should focus on increasing early detection rate and taking effective therapies.