基于适配子的分子探针在肿瘤分子影像学中的应用

Aptamers as molecular probes in tumor molecular imaging

理想的分子影像探针应具有一定的特异性、敏感性、安全性。适配子是可与靶分子高特异性和高亲和力结合的单链 DNA 或 RNA 分子，具有靶分子广泛、分子小、易生产和修饰、免疫原性低、渗透性强等特点，是一种新型的分子影像探针。目前基于适配子的肿瘤分子影像学研究越来越多，为肿瘤的诊断和治疗提供了新的技术和工具。

The ideal molecular imaging probe should have characteristics of specificity,sensitivity and safety.Aptamers are sing-strand DNA or RNA oligonucleotides which can bind their targets with high specificity and high affinity.Aptamers are new types of molecular imaging probe because they have many advantages,such as their large sum of possible targets,small molecule weights,easily production and modification,low immuno-genicity,high tissue penetration and so on.Now more and more aptamers research on tumor molecular imaging provides a new technology and tool for tumor diagnosis and therapy.