靶向 EphB4受体分子探针的研究进展

Advance of molecular imaging probes targeted for EphB4 receptor

促红细胞生成素产生肝细胞受体（Eph）B 型受体4与肿瘤生长和肿瘤血管形成密切相关，并且在许多肿瘤中过量表达。EphB4靶向探针可提高肿瘤诊断的准确性和特异性。大量针对该靶点的分子探针已经被设计出来，有望为肿瘤的早期诊断和治疗提供新的方法。

The erythropoietin-producing hepatocellular receptor （Eph）B4 receptor is closely associa-ted with tumor growth and angiogenesis,which is over-expressed in a wide variety of tumors.Molecular probes targeted for EphB4 receptor can improve the accuracy and specificity of tumor diagnosis.A lot of molecular probes targeted for EphB4 receptor have been designed,which are expected to provide new means for the early diagnosis and therapeutics of tumors.