基于2-卤甲基-3-喹啉甲酸乙酯的反应研究进展

Research progress on the reaction of ethyl 2-( halogenmethyl)quinoline-3-carboxylate

喹啉及其衍生物是一类重要的杂环化合物,许多具有生物活性的稠杂环化合物中都含有喹啉骨架。由2-卤甲基-3-喹啉甲酸乙酯合成多环或稠杂环化合物的研究进展还未见文献报道。为更好地了解这方面的研究动态,本文综述了近几年有2-卤甲基-3-喹啉甲酸乙酯参与反应的研究进展,主要涉及了2-氯(溴)甲基-3-喹啉甲酸乙酯与酚、胺、水杨醛和芳香醛等的一系列反应。

Quinoline and its derivatives are very important heterocyclic compounds,and many quinoline-containing heterocyclicfused compounds have been found to exhibit potent biological activities.To the best of our knowledge,there is not any review summarizing the literature on the use of ethyl 2-（ halogenmethyl） quinoline-3-carboxylate as the building blocks for synthesis of quinolinebearing polycyclic heterocyclic-fused systems.As such,in order to cover the recent work in this aspect,and provide useful and up-todate data for organic chemists,the present review focuses mainly on the reaction of ethyl 2-（ halogenmethyl） quinoline-3-carboxylate with phenols,amines,salicylaldehydes,aldehydes and so on.