300例帕金森病患者病机证素分布规律探讨

Discussion on Pathogenesis Essence of Parkinson's Disease Based on Distribution Regularity of TCM Syndrome Elements of 300 Cases

目的根据300例帕金森病患者的中医病机证素的分布及兼夹规律,探讨帕金森病的病机本质。方法采用流行病学横断面调查方法,对300例帕金森病患者中医病机证素进行分析,总结并归纳病机证素分布及兼夹特点。结果 8种病机证素一共出现1 180频次,其中风、阴虚、痰、瘀4种病机证素所占比例最多,分别为22.88%,22.12%,14.89%,17.54%,且以上4种病机证素兼夹患者占总患者数32.33%。结论肝肾阴虚是该病发生的病理基础,风痰瘀阻为中心病理环节;肝肾阴虚,风痰瘀阻证为该病的主要证型,因此滋补肝肾,化痰熄风通络法为本病主要治疗大法。

OBJECTIVE To discuss the pathogenesis essence of Parkinson＇s disease through analyzing the distribution regularities of syndrome elements in 300 cases.METHODS Epidemiological cross-sectional survey method was applied to analyze the pathogenesis syndrome elements of 300 cases with Parkinson＇s disease and summarize its distribution characteristics.RESULTS The total appearance frequency of the eight kinds of syndrome elements was 1180,and the top four pathogenesis syndrome elements are wind,yin deficiency,phlegm and stasis,with the corresponding data being 22.88%,22.12%,14.89%and 17.54% respectively.The proportion of patients with the above two or more pathogenesis syndrome elements was32.33%.CONCLUSION Liver-kidney yin deficiency is considered to be the basis of pathogenesis and wind-phlegm obstruction syndrome and stasis are the center pathogenesis,with the main syndrome type being liver-kidney yin deficiency and windphlegm obstruction.Hence,the main therapeutic method for this disease is to nourish liver and kidney,remove phlegm,eliminate wind and dredge collaterals.