具核梭杆菌与全身疾病相关性的研究进展

The relationship between Fusobacterium nucleatum and systemic diseases:Research progress

具核梭杆菌(Fusobacterium nucleatum,F.nucleatum)是在口腔微生态环境中常驻的一种革兰阴性专性厌氧菌,近来研究发现F.nucleatum不仅与口腔感染性疾病如牙周病、根尖周病等的发生、发展密切相关,而且与早产低体重儿、结直肠癌、呼吸道感染等全身疾病密切相关。本研究对F.nucleatum生物学功能及与口腔感染、全身疾病相关性的研究进展作一综述。

Fusobacterium nucleatumis an anaerobic oral commensal bacteria and a periodontal pathogen associated with a wide spectrum of human diseases.This article reviews the progress in research on its biological functions and its implication in oral infections,preterm low birth weight,colorectal cancer,and respiratory tract infections.