依达拉奉注射液联合甘油果糖治疗高血压性脑出血的临床疗效

Clinical Effect of Edaravone Combined with Glycerin Fructose in the Treatment of Hypertensive Cerebral Hemorrhage

目的:探讨依达拉奉联合甘油果糖治疗高血压性脑出血的临床疗效。方法:根据患者的意愿将120例高血压性脑出血患者分成观察组(56例)和对照组(64例)。对照组患者给予依达拉奉联合甘露醇治疗;观察组患者采用依达拉奉联合甘油果糖治疗15d。观察两组患者治疗后临床疗效、神经功能恢复评分及肾功能损害情况。结果:1观察组患者治疗后总有效率为73.21%(41/56),明显高于对照组患者总有效率35.9%(25/64),差异有统计学意义(P<0.05);2治疗后两组患者的NIHSS评分均低于治疗前,治疗后观察组患者NIHSS评分为(4.29±5.6)明显低于对照组患者评分(7.09±4.9),差异均有统计学意义(P<0.05);3治疗后观察组患者肾功能损害情况评分明显低于对照组患者,差异有统计学意义,(P<0.05)。结论:采用依达拉奉联合甘油果糖治疗高血压性脑出血患者,疗效确切且不良反应少,值得临床推广应用。

Objective： To investigate the clinical curative effect of edaravone combined with glycerin fructose on hypertensive cerebral hemorrhage. Methods： According to the patients’ willing, 120 patients with hypertensive cerebral hemorrhage were divided into control group and observation group. The 64 patients in control group were given edaravone and mannitol treatment; and the 56 patients in observation group were given edaravone and glycerin fructose treatment for 15 days. The clinical efficacy, neural functional recovery and kidney damage after treatment was observed and compared in two groups. Results： ① After treatment, the total effective rate in observation group was 73.21 %（41/56）, which was obviously higher than the 35.9 %（25/64）in control group, and the difference showed statistical significance（P〈0.05）; ②After treatment, the NIHSS scores in the two groups were both declined,and the NIHSS score in observation group was（4.29 ±5.6）,which was obviously lower than the（7.09 ±4.9）in control group, and the difference showed statistically significant（P〈 0.05）;③After treatment, the renal impairment scores in observation group was obviously lower than that in control group with statistical significance（P〈 0.05）. Conclusions： The treatment with edaravone and glycerin fructose for the patients of hypertensive cerebral hemorrhage shows exact clinical curative effect and less adverse reactions, which is worthy of clinical popularization and application.