间歇性双侧完全鼻阻塞对幼年大鼠下颌骨生长发育的影响

Effects of bilateral intermittent nasal obstruction on the mandibular growth and development in young rats

目的探讨间歇性双侧完全鼻阻塞对幼年大鼠下颌骨生长发育的影响。方法 30只3周龄SD大鼠,分为3组,A组:对照组,B组:单侧鼻阻塞组,C组:双侧鼻阻塞组(张口呼吸组),每组各10只。4周后处死30只大鼠,分离大鼠的下颌骨,在X线片上测量10项下颌骨的指标。结果双侧鼻阻塞组与对照组及单侧鼻阻塞组相比,下颌骨及股骨明显小,差异有统计学意义。单侧鼻阻塞组与对照组相比仅下颌体长度、下颌磨牙高度、股骨长度有统计学差异。结论间歇性双侧完全鼻阻塞可以引起大鼠下颌骨的发育不足。

Objective To investigate the effects of bilateral intermittent nasal obstruction on the mandibular growth and development of young rats. Methods Thirty 3- week-old SD rats were randomly distributed into three groups（ n = 10 each）. The experimental subjects were treated with single / both nostrils occluded with nose plugs,while the internal control group was left with blank treatment. The experimental subjects were sacrificed after 4 weeks and their mandibles were detached. Ten variables of mandibles were acquired based on X-rays. Results The subjects with bilateral nasal obstruction showed significant reduced mandible and femur in size compared to unilateral nasal obstruction group and control group. However,only length of mandibular body 、height of first molar in mandible and length of femur in unilateral nasal obstruction group showed significant difference compared to control group. Conclusion The bilateral intermittent nasal obstruction may retard the development of mandibles in rats.