胃肠安丸对功能性消化不良肝郁脾虚大鼠胃动素的影响

Effect of Weichang'an Pill on motilin in functional dyspepsia in liver stagnation and spleen deficiency rats

目的观察胃肠安丸对肝郁脾虚型功能性消化不良(FD)模型大鼠胃肠动力及血浆胃动素(MTL)水平的影响。方法将60只实验大鼠随机分为6组(每组10只):对照组,模型组,胃肠安丸高、中、低剂量(50.4、25.2、12.6 mg/kg,中剂量为临床等效剂量)组及多潘立酮片阳性对照组,各组均ig给药,连续7d。给药后测定每组大鼠胃残留率及血浆MTL水平。结果与模型组相比,胃肠安丸高、中剂量组及多潘立酮片组大鼠胃内残留率显著降低(P<0.05);胃肠安丸高剂量组血浆MTL水平与对照组、模型组相比均显著提高(P<0.05);胃肠安丸中剂量组血浆MTL水平显著高于模型组(P<0.05)。结论胃肠安丸可能通过调节MTL水平,改善胃动力,进而发挥对FD的治疗作用。

Objective To observe the effect of Weichang＇an Pill on regulating the gastrointestinal motility and plasma motilin （MTL） level in liver stagnation and spleen deficiency type of functional dyspepsia （FD） rat model. Methods Sixty rats were randomly divided into six groups （n = 10）： control group, model group, Weichang＇an pill high （50.4 mg/kg）, medium（25.2 mg/kg） and low （12.6 mg/kg） dose （middle dose for clinical equivalent dose） groups, Domperidone Tablets group as positive control group, all groups were intragastric administered for 7 d. The gastric remnant rate and plasma MTL level in rats were measured after administration. Results The gastric residual rate in Weichang＇an pill high dose group and Domperidone Tablets group decreased significantly compared with the model group （P 〈 0.05）; The plasma MTL levels in Weichang＇an pill high dose group were significantly increased compared with the control group and model group （P 〈 0.05）. The plasma MTL in Weichang＇an pill dose group was significantly higher than that of model group （P 〈 0.05）. Conclusion Weichang＇an Pill can regulate the MTL level so that improve gastric motility and furthermore play a therapeutic effect on FD.