B10细胞在器官移植术后免疫耐受中的研究现状和前景

Status quo and prospect of research on B10 cell in immune tolerance after organ transplantation

器官移植术后的理想目标是达到移植物的免疫耐受状态,相关研究显示调节性B细胞(regulatory B cells,Bregs)在诱导器官移植术后免疫耐受中有积极作用,但起主导作用的细胞表型和具体机制尚无共识。近年来B10细胞的发现进一步揭示了调节性B细胞诱导器官移植术后免疫耐受的相关机制,并有望最终诱导免疫耐受状态。本文就B10细胞的研究现状及其在器官移植免疫耐受中的作用、前景进行综述。

Immune tolerance is the ideal goal for organ transplantation. Related research shows regulatory B cells play an active role in immune tolerance after organ transplantation, but the cell phenotype and specific mechanism of regulatory B cells are still uncertain. In recent years, the discovery of B10 cells further reveals the mechanism of regulatory B cell in immune tolerance after organ transplantation. This article reviews recent researches on B10 cells and its role in immune tolerance after organ transplantation.