绝经后雌激素补充治疗对阴道微生态的影响

Effect of menopausal hormone therapy on the vaginal microecology

目的探讨绝经后激素补充治疗(MHT)对绝经女性阴道微生态的影响。方法选择妇科门诊就诊的绝经女性322例,按绝经时间分为≤5年组、>5年且<11年组和≥11年组;按照MHT使用与否分为使用MHT组(n=104)与未使用MHT组(n=218);取阴道分泌物进行微生态检测,比较各组阴道微生态的数据。结果细菌性阴道病在不同绝经时间组中的发病率最高,在≤5年组为21.1%、>5年且<11年组为19.3%、≥11年组为16.0%;使用MHT组菌群/功能异常的阳性率明显低于未使用MHT组(P<0.05);使用MHT组菌群正常率显著高于未使用MHT组(P<0.01)。结论细菌性阴道病是绝经女性常见的阴道感染性疾病之一。MHT有助于阴道微生态的改善。

Objective To study the effect of menopausal hormone therapy （MHT）on the vaginal microecology for postmenopausal women.Methods A total of 322 postmenopausal women in gynecology outpatient department were selected and divided into post-menopausal less than 5 years group,post-menopausal from 5 to10 years and post-menopa-usal more than 5 years group.According to the MHT treatment,and the patients were also divided into MHT group （MHT ＋,n =104）and never MHT use group （MHT -,n =218）.The changes of vaginal micro ecological environment were compared.Results Bacterial vaginosis（BV）was the most common disease in postmenopausal women.The positive rate of BV in different menopause groups were 21.1% in less than5 years group,19.3% in from 5 to 11 years group and 16.0% in more than 11years group,respectively.The positive rate of abnormalbacteria colonies/function in MHT ＋group was significantly lower than those in MHT - group （P 〈0.05）.Normal bacteria colonies in MHT ＋ group was significantly higher than those in MHT -（P 〈0.01）.Conclusions BV is one of the most common genital tract infections in postmenopausal women.MHT is helpful to improve the vaginal micro ecology.