帕罗西汀联合认知行为疗法治疗抑郁症35例

Clinical Effects of Paroxetine and Cognitive Behavior Therapy on the 35 Cases with Depression

目的:观察帕罗西汀联合认知行为疗法治疗抑郁症的临床效果。方法:病例资料来源于医院2014年2月至2015年1月就诊的抑郁症患70例者。随机分为药物组和药物+认知行为联合组(简称"联合组")。药物组单纯用帕罗西汀治疗;联合组采用帕罗西汀联合认知行为疗法治疗。比较两组治疗总有效率,以及干预前和干预1、2、4、8周患者汉密尔顿抑郁量表评分的差异。结果:1联合组对比药物组总有效率更高(P<0.05);2干预前两组汉密尔顿抑郁量表评分差异无统计学意义(P>0.05),干预后1、2、4、8周,联合组对比药物组汉密尔顿抑郁量表评分改善更显著(P<0.05)。结论:帕罗西汀联合认知行为疗法治疗抑郁症的临床效果确切,可有效改善患者抑郁症状。

Objective:To study the clinical effects of cognitive behavioral therapy combined with paroxetine in the treatment of depression.Methods:The case data had been collected from 70 patients with depression diagnosed and treated in the Fourth People's Hospital of Jingdezhen from February2014 to January 2015.70 patients had been randomly divided into the drug group and the combination group.The drug group had been treated with paroxetine alone,paroxetine combined with cognitive behavior therapy for the combination group.The total effective rate and the differences of Hamilton Depression Scale scores both before the intervention and in 1weeks,2weeks,4weeks and 8weeks after the intervention had been compared.Results:(1)the total efficiency in the combination groupwas significantly higher than the drug group(P<0.05);(2)the Hamilton Depression Scale scores of the two groups before the intervention were similar(P>0.05);Hamilton Depression Scale scores in the combination group after 1 weeks,2 weeks,4 weeks and 8 weeks intervention were improved more significantly than the drug group(P<0.05).Conclusion:The clinical effects of Paroxetine combined with cognitive behavioral therapy in the treatment of depression is effective,can effectively lessen depressive symptoms,and is worthy of promotion.