探讨醒脑静与纳洛酮在重型颅脑损伤后迁延性昏迷治疗中的临床疗效

Clinical effects of the Xingnaojing injection plus Naloxone on persistent coma after severe brain injury

目的:探究醒脑静与纳洛酮治疗重型颅脑损伤后迁延性昏迷的临床疗效。方法:选择2013年8月-2015年8月我院收治的72例重型颅脑损伤后迁延性昏迷患者,随机分为两组,观察组经醒脑静联合纳洛酮治疗,对照组仅经纳洛酮治疗,比较两组的疗效。结果:观察组总有效率为77.8%,显著高于对照组,具有统计学差异,P<0.05;观察组呼吸系统异常率为19.4%,心血管系统异常率为30.6%,均显著低于对照组,P<0.05;观察组GCS评分为(9.2±1.8)分,KPS评分为(76.8±7.4)分,均显著高于对照组,P<0.05。结论:醒脑静与纳洛酮治疗重型颅脑损伤后迁延性昏迷可有效改善患者昏迷症状,提高生活质量,降低呼吸与心血管事件的发生率,具有重要的临床价值。

Objective： Clinical effects of the Xingnaojing injection plus Naloxone on persistent coma after severe brain injury were investigated. Methods： 72 patients in our hospital were randomized into 2 groups. The observed group was given the Xingnaojing injection plus Naloxone; the control group took Naloxone barely. Clinical efficacy in groups were compared. Results： The total efficiency in the observed group was 77.8%, higher than that in the control group, P〈0.05. In the observed group, abnormal respiratory system was 19.4%; abnormal cardiovascular system is 30.6%, obviously lower than the control group, P〈0.05. In the observed group, GCS scores were（9.2±1.8） points; KPS scores were（76.8±7.4） points, both significantly higher than those in the control group, P〈0.05. Conclusion： The Xingnaojing injection plus Naloxone on persistent coma after severe brain injury could significantly improve clinical syndromes and life quality, reduce the incidence of respiratory and cardiovascular events, and was worthy of extensive application.