糖代谢异常与肿瘤发生发展

Dysregulation of glucose metabolism in tumorigenesis and tumor progression

细胞代谢异常和肿瘤发生发展密不可分,糖代谢异常在肿瘤代谢异常中表现得尤为突出。肿瘤细胞摄入大量葡萄糖,即使在供氧充足的情况下,也主要是通过糖酵解途径来产生能量和满足快速生长需求。糖代谢异常与肿瘤发生发展互为因果,肿瘤细胞代谢和信号转导网络互作来协同促进肿瘤发生发展。肿瘤相关基因的异常表达调控代谢网络,反之,异常的代谢酶或代谢物能够调控癌基因或抑癌蛋白。代谢酶作为细胞代谢的直接执行者,在肿瘤细胞糖代谢异常和肿瘤发生发展中发挥着关键作用。

Dysregulation of cell metabolism,especially glucose metabolism,is implicated in tumorigenesis and tumor progression. Cancer cells uptake a large amount of glucose and prefer to perform glycolysis in the cytosol even under normal oxygen condition,which fuels fast cell growth and proliferation. Dysregulation of glucose metabolism leads to tumorigenesis and promotes cancer development. Conversely,the initiation and development of cancer reprograms glucose metabolism to confer cancer cells the ability to survive and proliferate. Oncogenes,tumor suppressors or non-coding RNAs could regulate glucose metabolism. Meanwhile,the enzymes and metabolites involved in glucose metabolism could regulate the expression of factors related to cancer. Enzymes,the direct executor of cell metabolism,play a key role in dysregulation of glucose metabolism,tumorigenesis and tumor development.