氟哌噻吨美利曲辛辅助治疗肠易激综合征对患者血液学指标及肠敏感度的影响

Effect of Deanxit in treatment of irritable bowel syndrome on hematological index and intestinal sensitivity

目的探讨氟哌噻吨美利曲辛辅助治疗肠易激综合征对患者血液学指标及肠敏感度的影响。方法选取福建省人民医院消化科2013年1月-2015年6月收治的肠易激综合征患者82例,按随机数字表法分成2组,各41例,均接受维持水电解质和酸碱平衡等对症处理,对照组予以匹维溴胺及双歧三联活菌治疗,研究组在对照组治疗基础上予以氟哌噻吨美利曲辛辅助治疗,记录2组血液学指标、炎性因子指标及肠道敏感性指标,同时对比2组临床疗效。结果与治疗前相比,2组治疗后血浆生长抑素（Somatostatin,SS）、P物质（Substance P,SP）及5-羟色胺（5-Hydroxytryptamine,5-HT）水平均明显降低（P〈0.05）,神经肽Y（Neuropeptide Y,NPY）水平升高,TNF-α及IL-6、IL-8水平降低,IL-10水平升高,腹痛评分、腹胀评分及腹泻评分降低,差异均有统计学意义（P〈0.05）;相对于对照组,研究组治疗后血浆SS、SP及5-HT水平较低,NPY水平较高,TNF-α及IL-6、IL-8水平较低,IL-10水平较高,腹痛评分、腹胀评分及腹泻评分降低,差异均有统计学意义（P〈0.05）;研究组治疗有效率高于对照组（P〈0.05）。结论氟哌噻吨美利曲辛辅助治疗肠易激综合征疗效确切。

Objective To investigate the effect of Deanxit in treatment of Irritable bowel syndrome in patients in hematological index and intestinal sensitivity. Methods 82 cases with Irritable bowel syndrome were selected and divided into two groups,each had 41 cases. Control group was treated with conventional therapy,experiment group was treated on the base of the treatment with Deanxit. Hematology ndex and intestinal sensitivity index and clinical effect were compared after treatment. Results Compared with pre-treatment,plasma SS,SP and 5-HT decreased in two groups after treatment,NPY increased,levels of TNF-α,IL-6 and IL-8 decreased,levels of IL-10 increased,abdominal pain score,abdominal distension and diarrhea score score decreased,the differences were all significant（P〈0. 05）. Compared with control group,plasma SS,SP and 5-HT in the experiment group were lower,NPY was higher,levels of TNF-α,IL-6 and IL-8 were lower,levels of IL-10 were higher,abdominal pain score,abdominal distension and diarrhea score score were lower than control group,the differences were all significant（P〈0. 05）. Conclusion Deanxit in the treatment of Irritable bowel syndrome has curative effect.