银杏注射液联合前列地尔对突发性耳聋患者听力恢复程度、免疫球蛋白和血液指标的影响

Effect of ginkgo biloba injection combined with alprostadil on hearing recovery,immunoglobulin level and hemorheology indexes of patients with sudden deafness

目的探讨银杏注射液联合前列地尔对突发性耳聋听力恢复程度、免疫球蛋白和血液指标的影响。方法将2014年7月-2015年9月温州医科大学附属第一医院收治的82例突发性耳聋患者按照随机数字表法分为对照组（n=41）和试验组（n=41）,对照组患者给予前列地尔注射液10μg,加入100 m L 0.9%的生理盐水静滴,1次/天;试验组在对照组的基础上给予银杏注射液20 m L,加入500 m L 5%葡萄糖注射液静滴,1次/天。2 w后观察2组患者的临床疗效和听力恢复程度,分析血清中免疫球蛋白A（IgA）、免疫球蛋白G（Ig G）、免疫球蛋白M（Ig M）水平,检测全血黏度、血浆黏度、红细胞压积及红细胞聚集指数等血液流变学指标。结果治疗2 w后试验组患者总有效率为92.68%,明显高于对照组70.73%（χ^2=6.609,P=0.010）;试验组患者耳鸣、耳闷、眩晕等听力恢复程度均明显高于对照组（P〈0.05）;试验组患者的纯音听阈值低于对照组（P〈0.05）;治疗后2组患者血清Ig A、Ig G、Ig M均降低,且试验组患者明显低于对照组（P〈0.05）;治疗后2组患者的全血黏度、血浆黏度、红细胞压积及红细胞聚集指数均降低,且治疗组明显低于对照组（P〈0.05）。结论银杏注射液联合前列地尔可降低突发性耳聋的纯音听阈值,降低患者的免疫球蛋白水平,改善相关血液指标,提高临床疗效。

Objective To explore the effect of ginkgo biloba injection combined with alprostadil to hearing recovery,immunoglobulin level and hemorheology indexes of patients with sudden deafness. Methods 82 cases of sudden deafness patients collected in the first affiliated hospital of Wenzhou medical university from September 2015 to July 2014 were divided into control group（n = 41） and experimental group（n = 41） according to the random number table method. Control group were treated with 10 μg alprostadil injection,added to 100 m L 0. 9% saline infusion,intravenous drip,one time per day. Experimental group was given ginkgo biloba injection 20 m L,added to 500 m L 5% glucose intravenous drip on the basis of control group,one time per day. The clinical curative effect and hearing degree of recovery of two groups were observed after two weeks. Serum immunoglobulin A（Ig A）,immunoglobulin G（Ig G）,immunoglobulin M（Ig M） levels were tested by automatic biochemical analyzer. The whole blood viscosity,plasma viscosity,red cell pressure product and red cell aggregation index were tested by blood viscosity analyzer. Results Two weeks after treatment,the total effective rate of experimental group was 92. 68%,higher than 70. 73% of the control group（χ^2= 6. 609,P = 0. 010）. The tinnitus,aural fullness,vertigo and hearing recovery in experimental group was significantly higher than that of the control group,and the pure tone hearing threshold in experimental group was lower than the control group（P〈0. 05）. After treatment,serum Ig A,Ig G and Ig M levels were all decreased,and those indexes of experimental group were all significantly lower than those of control group（P〈0. 05）. The whole blood viscosity,plasma viscosity,red blood cell hematocrit and red blood cell aggregation index were decreased,and those indexes of experimental group were all significantly lower than that of the control group（P〈0. 05）. Conclusion The therapy of ginkgo biloba injection combined with alprostadil can reduce the tone of sudden deafness hearing threshold,promote the recovery of hearing,decreased in patients with immune globulin protein and hemorheology indexes,and improve clinical curative effect.