神经节苷脂对高血压脑出血术后患者神经功能的影响

Effect of ganglioside on nerve function in hypertensive cerebral hemorrhage after operation

目的探讨神经节苷脂对高血压脑出血术后患者神经功能的系统评价作用。方法选择2013年3月-2016年3月宁夏医科大学附属吴忠市人民医院收治的90名高血压脑出血术后患者随机分为对照组（常规治疗方式）和观察组（神经节苷脂治疗方式）,每组45名患者,观察2组患者治疗后的临床效果、神经功能评分、日常生活能力评分以及血肿、水肿情况。结果观察组患者临床总有效率（91.11%）明显高于对照组患者（66.67%）,差异具有统计学意义（P〈0.05）。治疗前2组患者血肿和水肿体积无统计学差异,治疗后第7天和第28天,观察组患者血肿和水肿的体积减少幅度与对照组相比优势明显,差异具有统计学意义（P〈0.05）。与治疗前相比,治疗后2组患者NIHSS评分以及ADL评分均出现明显的下降,差异具有统计学意义（P〈0.05）。与治疗后第7天和第28天NIHSS评分和ADL评分相比,观察组明显优于对照组,差异具有统计学意义（P〈0.05）。结论神经节苷脂应用于高血压脑出血术后的治疗中能够显著改善患者的神经功能,提高患者的治疗效果和生活能力,具有良好的临床预后价值。

Objective To investigate the effect of ganglioside on nerve function in patients with hypertensive cerebral hemorrhage after operation.Methods 90 cases with hypertensive cerebral hemorrhage after operation from March 2014 to March 2016 in our hospital were divided into control group and observation group,the control group was treated with routine treatment,the observation group was given ganglioside nerve cell nutrition therapy,the two groups of patients after treatment of clinical efficacy,neurological function score,ADL score,hematoma,edema were observed. Result The total effective rate（91. 11%） in the observation group was significantly higher than that in the control group（66. 67%）（P〈0. 05）,the difference was statistically significant. After 7 days and 28 days after treatment,the volume of hematoma and edema in the observation group was significantly decreased,and the control group had obvious advantages compared with the control group（P〈0. 05）. Compared with seventh days and twenty-eighth days after treatment,the NIHSS score and ADL score of the observation group were significantly better than the control group（P〈0. 05）,the difference was statistically significant. Conclusion The application of the ganglioside in the treatment of hypertensive cerebral hemorrhage can significantly improve the neurological function,improve the quality of life of patients and clinical treatment effect,has good clinical application value.