胰岛素泵短期强化干预联合生物合成人胰岛素治疗妊娠期糖尿病的临床疗效及对母婴结局的影响

Clinical efficacy of short term intensive insulin pump therapy and biosynthetic human insulin therapy and its effect on maternal and neonatal outcomes in gestational diabetes mellitus

目的探讨胰岛素合理应用对妊娠期糖尿病(gestational diabetes mellitus,GDM)的临床疗效。方法将GDM患者随机分为A、B 2组,B组采用胰岛素泵短期强化干预治疗,A组采用胰岛素泵短期强化干预联合生物合成人胰岛素治疗。结果经统计分析可知,B组孕前、分娩前体重指数及糖尿病家族史显著高于A组(P<0.05)。Logistic分析显示,孕前体重指数及糖尿病家族史分别是GDM需药物联合治疗的独立危险因素。A组患者血糖各指标改善程度、妊娠结局及新生儿危险因素发生情况优于B组(P<0.05)。结论合理应用胰岛素可提高临床治疗GDM的疗效,安全性较高。

Objective To investigate the clinical effect of insulin on gestational diabetes mellitus（GDM）. Methods GDM patients were randomly divided into group A and group B,group B were treated with short term intensive insulin pump therapy,and group A were treated with insulin pump in short term combined with biosynthetic human insulin therapy. Results The body mass index and diabetes family history rates pre-pregnancy in group B were significantly higher than group A（P〈0. 05）. Logistic analysis showed that family history of BMI pre-pregnancy and diabetes family history were independent risk factors for GDM drug treatment（P〈0. 05）. Compared with the group B,the improvement of blood glucose levels and the incidence of complications in patients with group A were better than the former（P〈0. 05）. Conclusion Rational application of insulin can improve the efficacy of clinical treatment of GDM,reduce the incidence of complications,with high safety.