脾多肽注射液对晚期高侵袭性肝癌患者血清生化学及肿瘤指标的影响

Effect of lienal polypeptide injection on serum biochemical and tumor markers in advanced highly aggressive liver cancer

目的探讨脾多肽对晚期高侵袭性肝癌患者血清生化学及肿瘤指标的影响。方法选取晚期高侵袭性肝癌患者60例,按随机数字表法分为2组,各30例,对照组予以肝动脉介入化疗联合常规治疗,研究组在对照组治疗基础上予以脾多肽注射液10m L,1次/2天,治疗1月后改为2次/周,共治疗6个月为一疗程,测定血清肿瘤标志物,取肝肿瘤组织测定基质金属蛋白、侵袭性相关指标,同时随访对比安全性状况。结果与治疗前相比,对照组治疗后CD3^+、CD4^+水平升高,研究组治疗后CD3^+、CD4^+及CD4^+/CD8^+水平升高,2组治疗后甲胎蛋白(alpha fetal protein,AFP)、癌胚抗原(carcino embryonie antigen,CEA)、糖类抗原CA125及CA199水平降低,基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶7(MMP-7)、基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶组织抑制因子-1(tissue inhibitor of metalloproteinase-1,TIMP-1)水平降低,肝癌衍生生长因子(hepatoma derived growth factor,HDGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)及微血管密度(microvascular vascular density,MVD)水平降低(P<0.05);与对照组相比,研究组治疗后CD3^+、CD4^+及CD4^+/CD8^+水平较高,AFP、CEA、CA125及CA199水平较低,MMP-2、MMP-7、MMP-9及TIMP-1水平较低,HDGF、VEGF及MVD水平较低(P<0.05)。结论脾多肽可以提高晚期高侵袭性肝癌患者免疫功能,降低肿瘤标志物及侵袭性相关指标水平,安全性高。

Objective To investigate the effect of lienal polypeptide injection on serum biochemical and tumor markers in the treatment of patients with advanced highly aggressive liver cancer. Methods 60 cases of advanced highly aggressive liver cancer in our hospital were selected and randomly divided into 2 groups,30 cases respectively. The control group received transcatheter arterial chemoembolization combined with routine treatment,and the experimental group received more with lienal polypeptide injection 10 m L once every 2 days,and after changed to two times weekly after 1 month,a total of 6 months for a course of treatment. Serum tumor markers,invasive and matrix metalloproteinase related indicators were determined,and the two groups were followed up,then compared safety condition after the treatment. Results Compared with before treatment,the levels of CD4^＋and CD3^＋in the control group after treatment increased,levels of CD3^＋,CD4^＋and CD4^＋/ CD8^＋in the experimental group increased,levels of alpha fetal protein（ AFP）,carcino embryonie antigen（ CEA）,CA125 and CA199 decreased in the two groups,levels of matrix metalloproteinase-2（ MMP-2）,MMP-7,MMP-9 and tissue inhibitor of metalloproteinase-1（ TIMP-1） decreased and levels of hepatoma derived growth factor（ HDGF）,vascular endothelial growth factor（ VEGF） and microvascular vascular density（ MVD） decreased（ P〈0. 05）,compared with the control group,the levels of CD3^＋,CD4^＋and CD4^＋/ CD8^＋in the experimental group after treatment were higher,levels of AFP,CEA,CA125 and CA199 were lower,levels of MMP-2,MMP-7,MMP-9 and TIMP-1 were lower,and levels of HDGF,VEGF and MVD were lower（ P〈0. 05）. Conclusion Lienal polypeptide injection can improve the immune function of patients with advanced highly aggressive liver cancer,and reduce the levels of tumor markers and invasive related indicators,with high safety.