体外受精/胞浆内单精子注射子代围生期结局的回顾性分析

The Perinatal Outcomes of Offsprings from IVF/ICSI:A Retrospective Study

目的:回顾性分析体外受精(IVF)/胞浆内单精子注射(ICSI)子代的围生期结局。方法:分析2012年1月—2013年12月在南京医科大学附属苏州医院接受辅助生殖技术(ART)治疗鲜胚和冻胚移植840个活产周期的临床资料和围生期结局。结果:双胎妊娠出生体质量([2 536.84±417.23)g vs.(3 314.67±466.56)g]和分娩孕周([36.78±1.74)周vs(.39.31±1.45)周]均低于单胎妊娠,差异有统计学意义(P<0.05);双胎妊娠早产发生率(45.66%vs.3.70%)、低出生体质量儿发生率(41.32%vs.2.41%)、剖宫产率(97.26%vs.81.64%)高于单胎妊娠,差异有统计学意义(P<0.05)。冻胚移植单胎妊娠出生体质量([3 358.96±458.34)g vs.(3 249.11±474.28)g]和剖宫产率(85.97%vs.74.58%)高于鲜胚移植,差异有统计学意义(P<0.05)。结论:IVF/ICSI技术获得的双胎妊娠较单胎妊娠不良围生期结局更多;在单胎妊娠中冻胚移植出生体质量和剖宫产率高于鲜胚移植。

Objective： Methodsclinical data and perinatal outcomes of 840 cycles of fresh embryo transfer or frozen-thawed embryo transfer（FET） were retrospectively analyzed in our hospital from January 2012 to December 2013. Results： The birth weight [（2 536.84±417.23）g vs.（3 314.67±466.56）g] and the gestational age[（36.78±1.74）week vs.（39.31±1.45） week] of the twins were significantly lower than singletons （P〈0.05）. The rates of premature birth （45.66% vs. 3.70%）, low birth weight（41.32% vs. 2.41%） and cesarean section（97.26% vs. 81.64%） in the twins were significantly higher than the singletons（P〈0.05）. The birth weight[（3 358.96±458.34）g vs. （3 249.11 ±474.28）g] and the cesarean section （85.97% vs. 74.58%）in the singletons of FET group were significantly higher than those in the fresh embryo transfer group （P〈0.05）. Conclusions： The twins of ART have more adverse perinatal outcomes than the singletons. The singletons of FET have better outcomes than the singletons of fresh embryo transfer.