恶性血液疾病患者发生医院感染的影响因素

Influencing factors of nosocomial infection for patients with malignant hematopathy

目的探讨恶性血液疾病患者发生医院感染的影响因素。方法选取本院血液科2012年1月至2015年5月收治的86例恶性血液疾病患者,根据是否发生医院感染,分为医院感染组和非医院感染组。统计患者的一般临床资料,分析潜在可疑危险因素与恶性血液病患者发生医院感染的关系,筛选发病的相关因素。结果 86例恶性血液病患者中34例发生医院感染,医院感染的发生率为39.53%。医院感染组和非医院感染组在合并糖尿病、预防性使用抗菌药物、使用糖皮质激素、住院时间、营养不良、中性粒细胞计数、中粒细胞缺乏时间、白细胞计数、血清白蛋白、血红蛋白和住院季节方面差异具有统计学意义(P均<0.05)。应用Logistic回归分析显示,合并糖尿病、预防性使用抗菌药物、使用糖皮质激素、住院时间、营养不良、中性粒细胞计数、白细胞计数、血清白蛋白、血红蛋白和住院季节为恶性血液疾病患者发生医院感染的独立影响因素(P均<0.05)。结论合并糖尿病、预防性使用抗菌药物、使用糖皮质激素、住院时间、营养不良、中性粒细胞计数、白细胞计数、血清白蛋白、血红蛋白和住院季节为恶性血液疾病患者发生医院感染的独立影响因素。

Objective To investigate the influencing factors of nosocomial infection for patients with malignant hematopathy. Methods Total of 86 patients with malignant hematologic diseases were selected in our hospital from January 2012 to May 2015, and divided into nosocomial infection group and non-nosocomial infection group according to whether with hospital infection. The general clinical data of patients were selected, while the relationship between potential risk factors and the incidence of nosocomial infection in patients with malignant blood diseases, and the relevant factors in the disease were analyzed. Results There were 34 cases with nosocomial infection among 86 hematologic malignancies cases, the nosocomial infection rate was 39.53%. Diabetes, antibiotics prophylactic using, corticosteroids using, length of hospital stay, malnutrition, neutrophil counting, agranulocytosis time, white blood cell counting, serum albumin, hemoglobin and season of hospital stay between nosocomial infection group and non-nosocomial infection group were statistically significant（P all 0.05）. The results of Logistic regression analysis showed that diabetes, antibiotics prophylactic using, corticosteroids using, length of hospital stay, malnutrition, neutrophil counting, white blood cell counting, serum albumin, hemoglobin and the season of hospital were independent factors of nosocomial infection in malignant diseases（P all 0.05）. Conclusions Diabetes, antibiotics prophylactic using, corticosteroids using, length of hospital stay, malnutrition, neutrophil counting, white blood cell counting, serum albumin, hemoglobin and the season of hospital were independent factors of nosocomial infection in malignant diseases.